C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress
M.E. Cicardi, Justin Hallgren, Darilang Mawrie, K. Krishnamurthy, Shashirekha S. Markandaiah, Andrew T. Nelson, V. Kankate, Eric Nathaniel Anderson, Piera Pasinelli, Udai Bhan Pandey, Christine M. Eischen, Davide Trotti
This study shows that C9orf72 poly(PR) causes nucleolar stress and neurotoxicity, which can be mitigated by reducing p53 levels in fly and rat models.
iScience · Jul 28, 2023Peer-reviewedNeuroscience