Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interaction
Jason Talkish, Haller Igel, Oarteze Hunter, Steven W. Horner, Nazish N. Jeffery, Justin R. Leach, Jermaine L. Jenkins, Clara L. Kielkopf, Manuel Ares
The paper identifies Cus2's role in splicing by binding to SF3b1 via a UHM-ULM interaction and shows its ATP-dependent removal is essential for pre-spliceosome formation.
RNA · May 20, 2019Peer-reviewedMolecular Biology