Haller Igel

The paper proposes a mechanism by which intron-lariat spliceosomes convert lariats into circular RNAs, suggesting a role in intron transposition.

The paper studies how different introns respond to splicing inhibitors in a humanized yeast strain, revealing intron-specific sensitivity and the impact of BP sequence variation.

The paper develops a method to profile single-molecule RNA modifications in yeast rRNA, revealing concerted modifications at functional centers and subpopulation changes in ribosome biogenesis.

The paper identifies over 150 new spliced regions in yeast genomes, termed protointrons, which are not conserved and may represent early stages of intron evolution.

The paper identifies Cus2's role in splicing by binding to SF3b1 via a UHM-ULM interaction and shows its ATP-dependent removal is essential for pre-spliceosome formation.