Manuel Ares

Extensive splicing deficiency in a degenerating mating-type chromosome

The paper identifies splicing deficiency in non-recombining mating-type chromosomes across phytoplankton species, showing how recombination suppression leads to transcript-level dysfunction.

Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkers

The paper identifies thousands of FLEXIs in human cells, links them to RNA-binding proteins, and suggests their potential as biomarkers.

Intron-lariat spliceosomes convert lariats to true circles: implications for intron transposition

The paper proposes a mechanism by which intron-lariat spliceosomes convert lariats into circular RNAs, suggesting a role in intron transposition.

Broad variation in response of individual introns to splicing inhibitors in a humanized yeast strain

The paper studies how different introns respond to splicing inhibitors in a humanized yeast strain, revealing intron-specific sensitivity and the impact of BP sequence variation.

Transposable elements drive intron gain in diverse eukaryotes

The paper identifies Introners, transposable elements driving intron gain in diverse eukaryotes, and finds they are prevalent in marine species and phylogenetically distant lineages.

Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling

The paper develops a method to profile single-molecule RNA modifications in yeast rRNA, revealing concerted modifications at functional centers and subpopulation changes in ribosome biogenesis.

Synthesis of modified nucleotide polymers by the poly(U) polymerase Cid1: Application to direct RNA sequencing on nanopores.

This paper tests the use of Cid1 to add poly(I) tails to RNA for direct nanopore sequencing, enabling detection of both poly(A) and non-poly(A) RNAs and nascent transcripts.

The UCSC SARS-CoV-2 Genome Browser

The paper describes a SARS-CoV-2 genome browser that integrates molecular data from multiple sources for visualization and analysis.

Rapidly evolving protointrons in Saccharomyces genomes revealed by a hungry spliceosome

The paper identifies over 150 new spliced regions in yeast genomes, termed protointrons, which are not conserved and may represent early stages of intron evolution.

Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interaction

The paper identifies Cus2's role in splicing by binding to SF3b1 via a UHM-ULM interaction and shows its ATP-dependent removal is essential for pre-spliceosome formation.

Autogenous Cross-Regulation Of Quaking mRNA Processing And Translation Balances Quaking Functions In Splicing And Translation

The paper investigates how Quaking isoforms Qk5 and Qk6 regulate each other's expression through post-transcriptional mechanisms, balancing their functions in splicing and translation.