Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders
Zinan Zhou, Lovelace J. Luquette, Guanlan Dong, Junho Kim, Jayoung Ku, K M Kim, Nandini Ramesh, Mingyun Bae, Ann H. Caplin, Diane D. Shao, Bezawit Sahile, Kow Essuman, Eitan Goodman, Michael B. Miller, August Yue Huang, , Christopher A. Walsh
The paper identifies a shared TOP1-mediated mutagenic mechanism in ALS, FTD, and AD through single-cell genomic analysis and experimental validation.
Cell · Jul 1, 2026Peer-reviewedGenomics