Jayoung Ku

Nuclear retention and RNA editing safeguard self-tolerance to immunogenic intron lariats

The paper investigates how intron lariats, especially those with transposable elements, trigger immune responses in cancer cells and shows that RNA editing and DBR1 depletion can be used to enhance anti-tumor effects.

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders

The paper identifies a shared TOP1-mediated mutagenic mechanism in ALS, FTD, and AD through single-cell genomic analysis and experimental validation.

Inverted Alu repeats in loop-out exon skipping across hominoid evolution

The paper identifies inverted Alu pairs that promote exon skipping through RNA stem-loop structures and shows their evolutionary significance in hominoid genomes.

Cellular dsRNA interactome reveals the regulatory map of exogenous RNA sensing

The paper identifies cellular dsRNA-binding proteins (dsRBPs) using anti-dsRNA immunoprecipitation and mass spectrometry, revealing their role in regulating the interferon response and antiviral defense against HCoV-OC43.

Alternative Polyadenylation Determines the Functional Landscape of Inverted Alu Repeats

The paper identifies alternative polyadenylation as a key mechanism by which inverted Alu repeats regulate gene expression and contribute to disease.

Mitochondrial dsRNAs activate PKR and TLR3 to promote chondrocyte degeneration in osteoarthritis

This study identifies mitochondrial dsRNAs as activators of PKR and TLR3, contributing to chondrocyte degeneration in osteoarthritis.