Author

Ann H. Caplin

Harvard UniversityORCID 0000-0002-3384-9049Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Christopher A. WalshiD· 2 shared Lovelace J. LuquetteiD· 2 shared Peter J. ParkiD· 2 shared Aaron Kleinman· 1 shared Abdel AbdellaouiiD· 1 shared Abhiram NatuiD· 1 shared Abraham A. PalmeriD· 1 shared Adam AutoniD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersGenomics

Christopher A. WalshORCID

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3 papers

Recent·Most cited

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders

Zinan Zhou, Lovelace J. Luquette, Guanlan Dong, Junho Kim, Jayoung Ku, K M Kim, Nandini Ramesh, Mingyun Bae, Ann H. Caplin, Diane D. Shao, Bezawit Sahile, Kow Essuman, Eitan Goodman, Michael B. Miller, August Yue Huang, , Christopher A. Walsh

The paper identifies a shared TOP1-mediated mutagenic mechanism in ALS, FTD, and AD through single-cell genomic analysis and experimental validation.

Cell · Jul 1, 2026Peer-reviewedGenomics

A comprehensive view of somatic mosaicism by single-cell DNA analysis

Lovelace J. Luquette, Tim H. H. Coorens, Abhiram Natu, Milovan Šuvakov, Ann H. Caplin, Mee Sook Jun, Alisa Mo, Joe Pelt, Lisa Anderson, Michele Berselli, Sravya Venkata Bhamidipati, Thomas P. Blanchard, Joseph Brew, Hye-Jung E. Chun, Hyunbin Chun, , Alexej S. Abyzov

The paper uses single-cell DNA sequencing to analyze somatic mosaicism in postmortem lung and colon tissues, revealing mutation heterogeneity, chromosomal abnormalities, and cellular ancestry.

bioRxiv · Oct 31, 2025 · PreprintGenomics

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Richard Karlsson Linnér, Pietro Biroli, Edward L. Kong, S. Fleur W. Meddens, Robbee Wedow, Mark Alan Fontana, Maël P. Lebreton, Abdel Abdellaoui, Anke R. Hammerschlag, Michel Guillaume Nivard, Aysu Okbay, Cornelius A. Rietveld, Pascal N. Timshel, Stephen P. Tino, Maciej Trzaskowski, , Jonathan P. Beauchamp

GWAS in over one million individuals identify 611 loci across risk tolerance and risky behaviors, revealing shared genetic architecture and implicating glutamatergic and GABAergic neurotransmission.

bioRxiv · Jan 8, 2019 · PreprintGenetics