Inflammatory Neuropathy in Mouse and Primate Models of Colorectal Cancer
Caitlyn M. Gaffney, Angela Maria Casaril, Iqbal Mahmud, Bo Wei, Yanyan Jiang, Nathan T. Fiore, Jialu Liu, K Valadez, Elizabeth A. Kolb, Fisher R. Cherry, Lei Shi, Kenneth Dunner, Philip L. Lorenzi, Steven R. Reiken, Peter M. Grace, , Andrew J. Shepherd
This study shows that colorectal cancer in mice and rhesus macaques causes inflammatory neuropathy with calcium dysregulation and myelin issues, suggesting a causal link to chronic neurological problems in cancer survivors.
Nature Communications · Aug 12, 2026Peer-reviewedNeuroscience