Author

Lei Shi

Chinese PLA General Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Neuroscience· 3 Bioinformatics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Organism:human· 2 Organism:rat· 2 Research Focus:spatial domain detection· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

Andrew J. ShepherdiD· 1 shared Angela Maria CasariliD· 1 shared Bin WaniD· 1 shared Bo WeiiD· 1 shared Caitlyn M. Gaffney· 1 shared Carolyn L. HodoiD· 1 shared Chen LiuiD· 1 shared Chunqiao LiuiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperNeuroscience

Andrew J. ShepherdORCID

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Author profile →

5 papers

Recent·Most cited

sfate: Schur-free, target-conditioned absorption probabilities for scalable single-cell fate analysis

Wei Zeng, Lei Shi

sfate computes annotation-targeted absorption probabilities by column-wise GMRES on a latent kNN graph, skipping Schur decomposition; a 74,984-cell mouse microglia analysis peaked at 1.76 GiB.

bioRxiv · Sep 25, 2026 · PreprintBioinformatics✦ In-depth digest

Inflammatory Neuropathy in Mouse and Primate Models of Colorectal Cancer

Caitlyn M. Gaffney, Angela Maria Casaril, Iqbal Mahmud, Bo Wei, Yanyan Jiang, Nathan T. Fiore, Jialu Liu, K Valadez, Elizabeth A. Kolb, Fisher R. Cherry, Lei Shi, Kenneth Dunner, Philip L. Lorenzi, Steven R. Reiken, Peter M. Grace, , Andrew J. Shepherd

This study shows that colorectal cancer in mice and rhesus macaques causes inflammatory neuropathy with calcium dysregulation and myelin issues, suggesting a causal link to chronic neurological problems in cancer survivors.

Nature Communications · Aug 12, 2026Peer-reviewedNeuroscience

Visualization of photoreceptor outer segment renewal using AAV-delivered Dendra2-tagged rhodopsin

Lijing Xie, Dianlei Guo, Xiaoyu Zhang, Yingchun Su, Lei Shi, Shujuan Xu, Rong Ju, Tiansen Li, Chunqiao Liu

This study uses AAV-delivered Dendra2-tagged rhodopsin to track photoreceptor outer segment renewal in mice, showing reduced renewal in a ciliopathy mutant.

bioRxiv · Nov 30, 2025 · PreprintCell Biology

Multimodal cortical connectome in the default mode network across the adult lifespan

Sanwang Wang, Xiaobo Liu, Jinzhi He, xiangwen chang, qiuxuan yu, Bin Wan, Zhen-Qi Liu, Weifeng Mi, Lei Shi

The paper examines age-related changes in multimodal connectivity within the default mode network using MRI and MEG data from adults aged 18 to 88.

bioRxiv · May 16, 2025 · PreprintNeuroscience

Automated 3D Inner Ear Assessment for Optimizing Animal Models of Noise-Induced Hearing Loss

Lei Shi, Yi Chun Du, Cong Wei, Wen-jie Huang, Handai Qin, Chen Liu, Liu Da, Shuolong Yuan, Qing‐qing Jiang, Jun Yang, Gang Li, Honglan Xie, Jianguo Zhao, Ning Yu, Shiming Yang

This paper develops an automated 3D inner ear modeling method to assess morphological similarities across species, finding mini pigs closely resemble humans in key structures.

bioRxiv · Sep 30, 2020 · PreprintNeuroscience