Andrew J. Shepherd

Inflammatory Neuropathy in Mouse and Primate Models of Colorectal Cancer

This study shows that colorectal cancer in mice and rhesus macaques causes inflammatory neuropathy with calcium dysregulation and myelin issues, suggesting a causal link to chronic neurological problems in cancer survivors.

Intrinsic Homeostatic Plasticity in Mouse and Human Sensory Neurons

This study shows that sustained depolarization reduces excitability in mouse and human sensory neurons through decreased voltage-gated sodium currents, suggesting homeostatic plasticity may be altered in chronic pain.

Astrocytes improve neuronal health after cisplatin treatment through mitochondrial transfer.

This study shows astrocytes transfer healthy mitochondria to cisplatin-damaged neurons, improving their survival, mitochondrial function, and calcium dynamics.

Macrophage-to-sensory neuron crosstalk mediated by Angiotensin II type-2 receptor elicits neuropathic pain

This study identifies macrophage AT2R activation as a key driver of neuropathic pain through ROS/NO-mediated TRPA1 activation in sensory neurons.