Author

K. A. Orlando

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

A. N. Karnezis· 3 shared B. E. Weissman· 3 shared D. G. Huntsman· 3 shared E. A. Raupach· 3 shared J. D. Lang· 3 shared J. M. Trent· 3 shared P. Pirrotte· 3 shared S. J. Facista· 3 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

A. N. Karnezis

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Author profile →

3 papers

Recent·Most cited

Landscape of super-enhancers in small cell carcinoma of the ovary, hypercalcemic type and efficacy of targeting with natural product triptolide

J. D. Lang, W. Selleck, S. Striker, N. A. Hipschman, R. Kofman, A. N. Karnezis, F. K. Kommoss, F. Kommoss, J. R. Wendt, S. J. Facista, W. P. Hendricks, K. A. Orlando, P. Pirrotte, E. A. Raupach, V. L. Zismann, , J. M. Trent

This paper identifies super-enhancer activity in SCCOHT driven by SMARCA4 loss and shows triptolide effectively inhibits tumor growth by targeting TFIIH at super-enhancers.

iScience · Feb 1, 2025Peer-reviewedCancer Biology

Novel functional insights revealed by distinct protein-protein interactions of the residual SWI/SNF complex in SMARCA4-deficient small cell carcinoma of the ovary, hypercalcemic type

E. A. Raupach, K. Garcia-Mansfield, R. Sharma, A. M. Hegde, V. David-Dirgo, Y. Wang, C. Young Shin, L. V. Tao, S. J. Facista, R. Moore, J. D. Lang, V. L. Zismann, K. A. Orlando, M. Spillman, A. N. Karnezis, , P. Pirrotte

This study identifies distinct protein-protein interactions of the residual SWI/SNF complex in SMARCA4-deficient SCCOHT cell lines, revealing altered functional consequences and potential synthetic lethal targets.

bioRxiv · Oct 6, 2019 · PreprintCancer Biology

Ponatinib shows potent antitumor activity in small cell carcinoma of the ovary hypercalcemic type (SCCOHT) through multi-kinase inhibition

J. D. Lang, W. P. D. Hendricks, H. Yin, J. Kiefer, P. Ramos, R. Sharma, P. Pirrotte, E. A. Raupach, C. Sereduk, N. Tang, W. S. Liang, M. Washington, S. J. Facista, V. L. Zismann, E. M. Cousins, , J. M. Trent

This paper identifies ponatinib as a potent treatment for SCCOHT by inhibiting multiple kinases in preclinical models.

bioRxiv · Jul 6, 2017Cancer Biology