H. Yin

The origin and evolution of cultivated rice and genomic signatures of heterosis for yield traits in super-hybrid rice

This study investigates the evolutionary history of cultivated rice and identifies genomic signatures of heterosis in super-hybrid rice varieties.

The impact of Bacillus coagulans X3 on available nitrogen content, bacterial community composition, and nitrogen functional gene levels when composting cattle manure

This study examines how adding Bacillus coagulans X3 to cattle manure compost affects nitrogen levels, bacterial communities, and nitrogen-related genes.

Discovery and Repurposing of Pharmaceutical Agents as Antifungals: In vivo activity against Coccidioides

The paper tests existing drugs for antifungal activity against Coccidioides in mice, finding that sertraline combined with fluconazole reduces lung fungal load.

Exploratory study of pulsed electric field ablation on atherosclerotic plaque in a rabbit model

This study investigates pulsed electric field ablation's effects on atherosclerotic plaques in rabbits, finding reduced lipid deposition, vascular remodeling, and increased elasticity.

Structural basis for the concerted antiphage activity in the SIR2-HerA system

This study determines the cryo-EM structures of SIR2, HerA, and their complex, revealing their structural basis for antiphage activity and functional interactions.

A Cholinergic Signaling Pathway underlying Cortical Circuit Regulation of Lateral Ventricle Quiescent Neural Stem Cells

This study identifies a cholinergic signaling pathway that activates quiescent neural stem cells in the lateral ventricle SVZ via cortical circuit stimulation.

Time is of the essence: A general framework for uncovering temporal structures of communities

This paper introduces a framework to analyze the temporal structure of ecological communities by focusing on sequence and duration, integrating temporal graph theory and phenology research.

Widespread readthrough events in plants reveal unprecedented plasticity of stop codons

The paper identifies widespread stop codon readthrough events in plants and reveals the plasticity of stop codons in encoding amino acids.

Long-term passaging of replication competent pseudo-typed SARS-CoV-2 reveals the antiviral breadth of monoclonal and bispecific antibody cocktails

This study evaluates the antiviral breadth of monoclonal and bispecific antibody cocktails against SARS-CoV-2 variants using a replication competent VSV-SARS-CoV-2 model, showing resistance to mutation in two cocktails.

AI inspired discovery of new biomarkers for clinical prognosis of liver cancer

This paper introduces PathFinder, an interpretable AI framework for discovering new tissue biomarkers in liver cancer, identifying tumor necrosis as a prognostic factor.

Immune defense in Drosophila melanogaster depends on diet, sex, and mating status

This study shows that mating status, sex, and diet affect immune defense in Drosophila melanogaster, with post-mating immunosuppression observed in both males and females.

Cost-efficient boundary-free surface patterning achieves high effective-throughput of time-lapse microscopy experiments

This study introduces a boundary-free surface patterning method that enhances the effective-throughput of time-lapse microscopy by preventing cell loss during long-term recordings.

Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase

This study reports cryo-EM structures of human enteropeptidase in multiple states, revealing its activation mechanism and substrate recognition process.

Efficient Neutralization of SARS-CoV-2 Omicron and Other VOCs by a Broad Spectrum Antibody 8G3

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

Comprehensive Evaluation of ACE2-Fc Combination with Neutralization Antibody on Broad Protection against SARS-CoV-2 and Its Variants

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

Fatigue Metabolites of Large Yellow Croaker and Construction of Swimming Model

This paper assesses swimming fatigue in large yellow croakers by analyzing metabolites and constructs an endurance swimming model to inform aquaculture site selection.

Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

THEM6-mediated lipid remodelling sustains stress resistance in cancer

This study identifies THEM6 as a marker of ADT resistance in prostate cancer, showing its role in lipid homeostasis and stress response, and highlights it as a potential therapeutic target.

Fusobacterium nucleatum facilitates cetuximab resistance in colorectal cancer via the PI3K/AKT and JAK/STAT3 pathways

Orthosteric-allosteric dual inhibitors of PfHT1 as selective anti-malarial agents

This paper develops dual orthosteric-allosteric inhibitors of PfHT1 that selectively target malaria parasites over human cells, showing potent activity against multidrug-resistant strains.

MicroRNA-1 promotes the development of and prolongs engorgement time in Hyalomma anatolicum anatolicum (Acari: Ixodidae) ticks

This study identifies miR-1 as a conserved microRNA in ticks that prolongs engorgement time and is differentially expressed across developmental stages.

Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing Aldob/Akt/PP2A protein complex

This study shows that loss of Aldob activates Akt, promoting hepatocellular carcinoma by destabilizing the Aldob/Akt/PP2A complex, and identifies SMAP as a potential therapeutic agent.

Metabolomic markers of colorectal tumor with different clinicopathological features

The paper identifies metabolic subtypes of colorectal cancer using metabolomics and finds correlations between these subtypes and clinical outcomes.

An in vitro vesicle formation assay to analyze protein sorting in the secretory transport pathway

The paper develops an in vitro vesicle formation assay to identify proteins involved in cargo sorting and trafficking, revealing novel regulators like FAM84B and PRRC1.

Mitochondrial dysfunction and autophagy responses to skeletal muscle stress

This study investigates autophagy and mitochondrial function in skeletal muscle under different stress conditions, finding that freeze injury causes mitochondrial dysfunction and autophagy scales with injury severity.

Single-cell RNA-seq analysis reveals the crucial role of Collagen Triplex Helix Repeat Containing 1 (CTHRC1) cardiac fibroblasts for ventricular remodeling after myocardial infarction

This study identifies a pro-fibrotic fibroblast subpopulation in mice after myocardial infarction, showing CTHRC1's role in ventricular remodeling and cardiac function.

PGC-1α overexpression partially rescues impaired oxidative and contractile pathophysiology following volumetric muscle loss injury

This study shows that PGC-1α overexpression improves oxidative capacity and muscle strength in VML-injured muscle, suggesting it as a potential therapeutic target.

DNA segment of African Swine Fever Virus first detected in hard ticks from sheep and bovine

The study detects a 235-bp DNA segment from African Swine Fever Virus in hard ticks from sheep and bovine, showing 99% identity with ASFV and suggesting a new strain.

Regrowth-delay Body as a Bacterial Subcellular Structure marking multidrug tolerant Persisters

The paper identifies a new subcellular structure, the regrowth-delay body, in bacterial persisters and links its presence to multidrug tolerance and regrowth delay.

The role of BMP6 in the proliferation and differentiation of chicken cartilage cells

This study investigates BMP6's role in chicken cartilage cell proliferation and differentiation, finding it regulates key signaling pathways and gene expression.