Author

P. Pirrotte

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Assay:proteomics· 5 Research Focus:drug response / drug discovery· 4 Research Focus:cell type annotation· 3 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. N. Karnezis· 4 shared B. E. Weissman· 4 shared D. G. Huntsman· 4 shared J. M. Trent· 4 shared K. Garcia-Mansfield· 4 shared R. Sharma· 4 shared Y. Wang· 4 shared E. A. Raupach· 3 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

A. N. Karnezis

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Landscape of super-enhancers in small cell carcinoma of the ovary, hypercalcemic type and efficacy of targeting with natural product triptolide

J. D. Lang, W. Selleck, S. Striker, N. A. Hipschman, R. Kofman, A. N. Karnezis, F. K. Kommoss, F. Kommoss, J. R. Wendt, S. J. Facista, W. P. Hendricks, K. A. Orlando, P. Pirrotte, E. A. Raupach, V. L. Zismann, , J. M. Trent

This paper identifies super-enhancer activity in SCCOHT driven by SMARCA4 loss and shows triptolide effectively inhibits tumor growth by targeting TFIIH at super-enhancers.

bioRxiv · Sep 8, 2023Cancer Biology

Defining the Caprin-1 interactome in unstressed and stressed conditions

L. Vu, A. Ghosh, C. Tran, W. A. Tebung, H. Sidibé, K. Garcia-Mansfield, V. David-Dirgo, R. Sharma, P. Pirrotte, R. Bowser, C. Vande Velde

The paper identifies the Caprin-1 interactome under unstressed and stressed conditions, revealing novel components of stress granules and their association with ALS aggregates.

bioRxiv · Jan 6, 2021Cell Biology

Dynamic multi-OMICs of glioblastoma reveal sensitivity to neddylation inhibition dependent on nuclear PTEN and DNA replication pathways

S. R. Ferdosi, B. Taylor, M. Lee, S. Peng, N. Tang, R. Bybee, G. Reid, L. Hartmen, K. Garcia-Mansfield, R. Sharma, P. Pirrotte, F. Furnari, H. D. Dhruv, M. E. Berens

The paper investigates the dynamic multi-OMICs of glioblastoma and identifies sensitivity to neddylation inhibition, though the manuscript was withdrawn due to un reproducible findings.

bioRxiv · Jul 21, 2020 · PreprintCancer Biology

Molecular profiling of innate immune response mechanisms in ventilator-associated pneumonia

K. V. PATHAK, M. I. McGilvrey, C. K. Hu, K. Garcia-Mansfield, K. Lewandoski, Z. Eftekhari, Y.-C. Yuan, F. Zenhausern, E. Menashi, P. Pirrotte

This study profiles proteome and metabolome changes in endotracheal aspirates (ETA) and bronchoalveolar lavage (BAL) from VAP patients to identify early host-pathogen interactions.

bioRxiv · Jan 8, 2020Immunology

Arginine depletion through ADI-PEG20 to treat argininosuccinate synthase deficient ovarian cancer, including small cell carcinoma of the ovary, hypercalcemic type

J. X. Ji, D. R. Cochrane, B. Tessier-Cloutier, S. Chen, G. Ho, K. V. Pathak, I. Alcazar, D. Farnell, S. Leung, A. Cheng, C. Chow, S. Colborne, G. Luca Negri, F. Kommoss, A. N. Karnezis, , D. G. Huntsman

This paper identifies ASS1 deficiency in rare ovarian cancers and shows that ADI-PEG20 inhibits tumor growth in ASS1-deficient models.

bioRxiv · Nov 17, 2019 · PreprintCancer Biology

Novel functional insights revealed by distinct protein-protein interactions of the residual SWI/SNF complex in SMARCA4-deficient small cell carcinoma of the ovary, hypercalcemic type

E. A. Raupach, K. Garcia-Mansfield, R. Sharma, A. M. Hegde, V. David-Dirgo, Y. Wang, C. Young Shin, L. V. Tao, S. J. Facista, R. Moore, J. D. Lang, V. L. Zismann, K. A. Orlando, M. Spillman, A. N. Karnezis, , P. Pirrotte

This study identifies distinct protein-protein interactions of the residual SWI/SNF complex in SMARCA4-deficient SCCOHT cell lines, revealing altered functional consequences and potential synthetic lethal targets.

bioRxiv · Oct 6, 2019 · PreprintCancer Biology

Ponatinib shows potent antitumor activity in small cell carcinoma of the ovary hypercalcemic type (SCCOHT) through multi-kinase inhibition

J. D. Lang, W. P. D. Hendricks, H. Yin, J. Kiefer, P. Ramos, R. Sharma, P. Pirrotte, E. A. Raupach, C. Sereduk, N. Tang, W. S. Liang, M. Washington, S. J. Facista, V. L. Zismann, E. M. Cousins, , J. M. Trent

This paper identifies ponatinib as a potent treatment for SCCOHT by inhibiting multiple kinases in preclinical models.

bioRxiv · Jul 6, 2017Cancer Biology