R. Moore

Loss of TRIM21 drives UVB-induced systemic inflammation by regulating DNA-sensing pathways

This study shows that loss of TRIM21 increases UVB-induced systemic inflammation by enhancing IFN expression through impaired STING signaling in mice.

Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging

This study identifies how DNMT3A and TET2 mutations in hematopoietic stem cells confer a selective advantage by reducing inflammation and aging effects.

Intradisciplinary Growth of Sustainability-Minded Engineers through Conservation Technology

This paper assesses how a project-based course on conservation technology shapes students' identities as sustainability-minded engineers and conservationists.

A highly conserved and globally prevalent cryptic plasmid is among the most numerous mobile genetic elements in the human gut

The paper identifies a highly prevalent cryptic plasmid in the human gut that is more numerous than crAssphage and has potential applications in detecting fecal contamination and inflammatory states.

Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques

This study evaluates an intranasal parainfluenza virus-vectored SARS-CoV-2 vaccine in macaques, showing it induces mucosal and systemic immunity and protects against viral challenge.

Detecting and quantifying clonal selection in somatic stem cells

This study introduces SCIFER, a method to detect and quantify clonal selection in somatic stem cells, revealing accelerated stem cell division in clonal hematopoiesis.

Targeting Vitamin-D receptor (VDR) by a small molecule antagonist MeTC7 inhibits PD-L1 but controls THMYCN neuroblastoma growth PD-L1 independently

This study shows that MeTC7, a VDR antagonist, reduces PD-L1 expression in cancer cells and inhibits neuroblastoma growth independently of PD-L1.

PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

This study shows that PD-1 blockade worsens Mycobacterium tuberculosis infection in rhesus macaques by increasing bacterial loads and altering immune responses.

Septins disruption controls tumor growth and enhances efficacy of Herceptin

The paper develops UR214-9, a compound that disrupts septin filaments in cancer cells, inhibiting growth of HER2+ tumors and enhancing Herceptin efficacy.

Novel functional insights revealed by distinct protein-protein interactions of the residual SWI/SNF complex in SMARCA4-deficient small cell carcinoma of the ovary, hypercalcemic type

This study identifies distinct protein-protein interactions of the residual SWI/SNF complex in SMARCA4-deficient SCCOHT cell lines, revealing altered functional consequences and potential synthetic lethal targets.

High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma

This study uses high-resolution 3D genome maps to identify CD276 as a therapeutic target in glioblastoma stem cells, showing it can suppress self-renewal.

Subclonal architecture, evolutionary trajectories and patterns of inheritance of germline variants in pediatric glioblastoma

This study examines genetic heterogeneity and evolutionary patterns in pediatric glioblastoma using whole-genome sequencing of germline-tumor pairs, revealing subclonal architecture and complex inheritance mechanisms.

Comprehensive characterization of pediatric AML reveals diverse fusion oncoproteins and age-specific mutational interactions

This study characterizes the molecular landscape of pediatric AML, identifying age-specific mutations and fusion oncoproteins that differ from adult AML.