A novel glucocorticoid and androgen receptor modulator reduces viral entry and innate immune inflammatory responses in the Syrian Hamster model of SARS-CoV-2
S. M. Rocha, A. C. Fagre, A. S. Latham, K. A. Popichak, C. P. McDermott, C. C. Dawson, J. Lewis, P. Reigan, T. A. Aboellail, R. C. Kading, T. Schountz, N. D. Theise, R. A. Slayden, R. B. Tjalkens
This paper shows that PT150, a glucocorticoid and androgen receptor antagonist, reduces SARS-CoV-2 replication and inflammatory responses in Syrian hamsters.
bioRxiv · Feb 20, 2021Immunology