Author

N. D. Theise

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Pathology· 2 Immunology· 1 Microbiology· 1 Pharmacology & Toxicology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

R. G. Wells· 5 shared J. Llewellyn· 4 shared A. E. Loneker· 2 shared A. R. Arment· 2 shared B. Zeck· 2 shared L. Chiriboga· 2 shared A. C. Fagre· 1 shared A. D. Glass· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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5 shared papersPhysiology

R. G. Wells

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Biliatresone treatment of pregnant mice causes changes in bile metabolism and liver inflammation in their offspring

K. Gupta, J. P. Xu, T. Diamond, I. de Jong, A. D. Glass, J. Llewellyn, N. D. Theise, J. D. Winkler, E. M. Behrens, C. Mesaros, R. G. Wells

This study shows that prenatal exposure to low-dose biliatresone in mice leads to altered bile metabolism and liver inflammation in offspring without histological damage.

bioRxiv · Mar 2, 2023 · PreprintPharmacology & Toxicology

Glisson's capsule structure and function is altered in cirrhotic patients irrespective of etiology

J. Llewellyn, C. Fede, A. E. Loneker, C. S. Friday, M. W. Hast, N. D. Theise, E. E. Furth, M. Guido, C. Stecco, R. G. Wells

This study examines changes in Glisson's capsule in liver disease, finding increased thickness and cellularity in cirrhosis regardless of cause, altered matrix composition, and reduced mechanical stiffness.

bioRxiv · Aug 28, 2022 · PreprintPhysiology

Eradicating Citrus Greening By Dual Action Targeting of Liberibacter asiaticus and Diaphorina citri.

C. Farrell, E. Triplett, N. D. Theise, C. A. Lowell, A. R. Arment

This paper investigates compounds that inhibit both Liberibacter asiaticus and Diaphorina citri, proposing a dual-action strategy to combat citrus greening.

bioRxiv · Feb 7, 2022 · PreprintPlant Biology

A novel glucocorticoid and androgen receptor modulator reduces viral entry and innate immune inflammatory responses in the Syrian Hamster model of SARS-CoV-2

S. M. Rocha, A. C. Fagre, A. S. Latham, K. A. Popichak, C. P. McDermott, C. C. Dawson, J. Lewis, P. Reigan, T. A. Aboellail, R. C. Kading, T. Schountz, N. D. Theise, R. A. Slayden, R. B. Tjalkens

This paper shows that PT150, a glucocorticoid and androgen receptor antagonist, reduces SARS-CoV-2 replication and inflammatory responses in Syrian hamsters.

bioRxiv · Feb 20, 2021Immunology

Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic steatohepatitis development in chimeric mice

M. Kabbani, E. Michailidis, S. Steensels, C. G. Fulmer, J. M. Luna, J. Le Pen, M. Tardelli, B. Razooky, I. Ricardo-Lax, C. Zou, B. Zeck, A. F. Stenzel, C. Quirk, L. Foquet, A. W. Ashbrook, , Y. P. de Jong

This study shows that the PNPLA3 148M variant in human hepatocytes worsens non-alcoholic steatohepatitis in chimeric mice on a hypercaloric diet.

bioRxiv · Nov 19, 2020 · PreprintPathology

Interstitial spaces are continuous across tissue and organ boundaries in humans

O. Cenaj, D. H. R. Allison, R. Imam, B. Zeck, L. M. Drohan, L. Chiriboga, J. Llewellyn, C. Z. Liu, Y. N. Park, R. G. Wells, N. D. Theise

The paper tracks particles and hyaluronic acid to show interstitial spaces are continuous across tissue and organ boundaries in humans.

bioRxiv · Aug 7, 2020Pathology

PT150 is a modulator of glucocorticoid and androgen receptors with antiviral activity against SARS-CoV-2.

N. D. Theise, A. R. Arment, D. Chakravarty, J. M. H. Gregg, I. M. Jacobson, K. H. Jung, S. S. Nair, A. Tiwari, A. W. Thurston, J. Van Drie, J. B. Westover

PT150 inhibits SARS-CoV-2 with EC90 5.55 M in human bronchial epithelial cells by downregulating AR and modulating ACE2 and TMPRSS2.

bioRxiv · Jul 12, 2020Microbiology

Lipid droplets disrupt mechanosensing in human hepatocytes

L. Chin, N. D. Theise, A. E. Loneker, P. A. Janmey, R. G. Wells

This study shows that lipid droplets in hepatocytes disrupt mechanosensing by altering YAP nuclear localization and affecting cell spreading and focal adhesions.

bioRxiv · Mar 31, 2020Physiology

Coordinated development of the mouse extrahepatic bile duct: implications for neonatal susceptibility to biliary injury

G. Khandekar, J. Llewellyn, A. Kriegermeier, O. Waisbourd-Zinman, N. Johnson, Y. Du, R. Giwa, X. Liu, T. Kisseleva, P. A. Russo, N. D. Theise, R. G. Wells

This study identifies four key anatomical and functional differences between neonatal and adult mouse extrahepatic bile ducts that may explain their susceptibility to injury.

bioRxiv · Mar 13, 2019Physiology