T. Schountz

Limited Cell-Autonomous Anticancer Mechanisms in Long-Lived Bats

This study shows that bat fibroblasts require fewer oncogenic hits for malignant transformation compared to other long-lived mammals, suggesting reliance on non-cell autonomous tumor suppression mechanisms.

Diet-induced changes in metabolism influence immune response and viral shedding dynamics in Jamaican fruit bats

The study shows diet affects viral shedding in Jamaican fruit bats, with suboptimal-sugar diets leading to higher viral RNA shedding than suboptimal-fat diets.

Regulatory T Cell-like Response to SARS-CoV-2 in Jamaican Fruit Bats Transduced with Human ACE2

This study shows Jamaican fruit bats are poorly susceptible to SARS-CoV-2 but develop a regulatory T cell-like immune response when transduced with human ACE2, leading to lung infection without overt disease.

SARS-CoV-2 infects multiple species of North American deer mice and causes clinical disease in the California mouse

This study shows SARS-CoV-2 infects multiple North American deer mice and causes clinical disease in California mice, suggesting potential wildlife reservoirs and co-morbidity factors for severe COVID-19.

Assessing the zoonotic potential of a novel bat morbillivirus

This study identifies a novel bat morbillivirus, MBaMV, and assesses its zoonotic potential by showing it can infect human cells but is restricted by human immune responses.

A novel glucocorticoid and androgen receptor modulator reduces viral entry and innate immune inflammatory responses in the Syrian Hamster model of SARS-CoV-2

This paper shows that PT150, a glucocorticoid and androgen receptor antagonist, reduces SARS-CoV-2 replication and inflammatory responses in Syrian hamsters.

A potent SARS-CoV-2 neutralizing human monoclonal antibody that reduces viral burden and disease severity in Syrian hamsters

Development of SARS-CoV-2 Nucleocapsid Specific Monoclonal Antibodies

This study develops and characterizes mouse monoclonal antibodies specific to SARS-CoV-2 nucleocapsid protein, tested using ELISA, western blot, and immunofluorescence.

SARS-CoV-2 infection, neuropathogenesis and transmission among deer mice: Implications for reverse zoonosis to New World rodents

This study infects deer mice with SARS-CoV-2, showing robust replication and potential for natural transmission, with a new spike protein mutation emerging during in vivo passage.