Author

K. B. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. A. Largaespada· 3 shared C. L. Moertel· 2 shared A. C. Hirbe· 1 shared A. Calizo^· 1 shared A. L. Crampton· 1 shared A. R. Marley· 1 shared A. T. Larsson· 1 shared A. T. Larsson^· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

D. A. Largaespada

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Author profile →

3 papers

Recent·Most cited

Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumors

K. B. Williams, A. T. Larsson, B. J. Keller, K. E. Chaney, R. L. Williams, T. A. Jubenville, M. M. Bhunia, G. M. Draper, C. L. Moertel, N. Ratner, D. A. Largaespada

This study identifies 23 compounds that selectively kill NF1-deficient Schwann cells and shows their efficacy in vivo, with synergy when combined with Selumetinib.

bioRxiv · Mar 25, 2024Cancer Biology

Perinatal folate levels do not influence tumor latency or multiplicity in a model of NF1 associated plexiform-like neurofibromas

A. R. Marley, K. B. Williams, J. Tibbitts, C. L. Moertel, K. Johnson, M. A. Linden, D. A. Largaespada, E. L. Marcotte

This study investigates whether pregestational folate intake affects tumor latency and multiplicity in a transgenic NF1 mouse model, finding no significant differences in tumor outcomes across folate groups.

bioRxiv · Jan 13, 2023 · PreprintCancer Biology

Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology

H. Bhatia^, A. T. Larsson^, A. Calizo^, K. Pollard, X. Zhang, E. Conniff, J. F. Tibbitts, S. H. Osum, K. B. Williams, A. L. Crampton, T. Jubenville, D. Schefer, K. Yang, Y. Lyu, J. Bade, , A. C. Hirbe

The paper develops an ex vivo 3D microtissue model of MPNST that captures genomic diversity and predicts in vivo drug response.

bioRxiv · Apr 29, 2022 · PreprintCancer Biology