Author

N. Ratner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Di Giannatale· 1 shared A. T. Larsson· 1 shared B. J. Keller· 1 shared C. Blanco· 1 shared C. L. Moertel· 1 shared C. P. Theuer· 1 shared C. Romagosa Perez-Portabella· 1 shared C. S. Thomson· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCancer Biology

A. Di Giannatale

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumors

K. B. Williams, A. T. Larsson, B. J. Keller, K. E. Chaney, R. L. Williams, T. A. Jubenville, M. M. Bhunia, G. M. Draper, C. L. Moertel, N. Ratner, D. A. Largaespada

This study identifies 23 compounds that selectively kill NF1-deficient Schwann cells and shows their efficacy in vivo, with synergy when combined with Selumetinib.

bioRxiv · Mar 25, 2024Cancer Biology

Endoglin, a novel biomarker and therapeutical target to prevent malignant peripheral nerve sheath tumor growth and metastasis

T. Gonzalez-Munoz, A. Di Giannatale, S. Garcia-Silva, V. Santos, S. Sanchez-Redondo, C. Savini, O. Grana-Castro, C. Blanco, D. J. Pisapia, J. L. Peralto, C. Romagosa Perez-Portabella, R. Alaggio, M. S. Benassi, L. Pazzaglia, K. Scotlandi, , H. Peinado

This study identifies endoglin (ENG) as a biomarker and therapeutic target for MPNSTs, showing that targeting ENG with antibodies or combining it with MEK inhibitors reduces tumor growth and metastasis.

Clinical Cancer Research · Jul 11, 2023Peer-reviewedCancer Biology

Merlin Tumor Suppressor Function is Regulated by PIP2-Mediated Dimerization

R. F. Hennigan, C. S. Thomson, N. Ratner, N. Nassar, K. Stachowski

This study shows Merlin dimerization is regulated by PIP2-mediated conformational changes and phosphorylation, with implications for its tumor suppressor function.

bioRxiv · Nov 11, 2021Cancer Biology