D. A. Largaespada

Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumors

This study identifies 23 compounds that selectively kill NF1-deficient Schwann cells and shows their efficacy in vivo, with synergy when combined with Selumetinib.

CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon restoration of RB function in malignant peripheral nerve sheath tumors

This study shows that combining SHP2 inhibitor TNO155 with CDK4/6 inhibitor enhances anti-tumor activity in MPNST by restoring RB function and overcoming resistance.

Perinatal folate levels do not influence tumor latency or multiplicity in a model of NF1 associated plexiform-like neurofibromas

This study investigates whether pregestational folate intake affects tumor latency and multiplicity in a transgenic NF1 mouse model, finding no significant differences in tumor outcomes across folate groups.

RAD-TGTs: Measurement of cellular tensions via flow cytometry and DNA sequencing enabled by force-dependent rupture and delivery of DNA tension probes

The paper introduces RAD-TGTs, a method to measure cellular tensions using DNA duplexes that rupture under force, with readout via flow cytometry and DNA sequencing.

In vivo functional genomics identifies essentiality of potassium homeostasis in medulloblastoma

The paper identifies potassium homeostasis as essential for medulloblastoma maintenance using a novel transposon system in mice and human samples.

Differential migration mechanics and immune responses of glioblastoma subtypes

This study shows mesenchymal glioblastoma cells migrate faster and generate more traction force than proneural cells, but their immunologically hot environment improves survival despite aggressive growth.

Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology

The paper develops an ex vivo 3D microtissue model of MPNST that captures genomic diversity and predicts in vivo drug response.

Multivalent, Bispecific ????B7-H3-????CD3 Chemically Self-Assembled Nanorings Direct Potent T-cell Responses Against Medulloblastoma

This paper designs and tests bispecific nanorings targeting B7-H3 and CD3 to enhance T-cell responses against medulloblastoma, showing improved tumor infiltration and reduced toxicity.

CD200 immune checkpoint reversal at the site of tumor vaccine inoculation: A novel approach to glioblastoma immunotherapy

This paper demonstrates that a CD200 peptide inhibitor enhances immune response in glioblastoma by reversing tumor-induced immunosuppression and downregulating PD-1 receptors.