Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection
X. Lin, B. Fu, Y. Xiong, N. Xing, W. Xue, D. Guo, M. Y. Zaky, K. C. Pavani, D. Kunec, J. Trimpert, H. Wu
This study identifies unconventional secretion of unglycosylated ORF8 as critical for inducing cytokine storms during SARS-CoV-2 infection by interacting with IL17RA on macrophages.
bioRxiv · Dec 3, 2021Microbiology