K. Cook

Effect of Artificial Lung Fiber Bundle Geometric Design on Micro- and Macro-scale Clot Formation

This study examines how geometric parameters of artificial lung fiber bundles affect clot formation and proposes design changes to reduce thrombosis and improve efficiency.

Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells

This study shows that metabolic activity in cancer cells affects circadian rhythms, with hypermetabolic states linked to weaker circadian oscillations in both mouse and human tumor cells.

A fibrin enhanced thrombosis model for medical devices operating at low shear regimes or large surface areas

This paper develops a computational model of thrombosis that incorporates fibrin formation through contact activation of factor XII, validating it against experimental data from low-shear medical devices.

Characterisation and sequence mapping of large RNA and mRNA therapeutics using mass spectrometry

This study develops an automated workflow for rapid characterization and sequence mapping of large RNA and mRNA therapeutics using mass spectrometry.

Coral assemblages at higher latitudes favour short-term potential over long-term performance

The paper examines how coral assemblages at higher latitudes prioritize short-term potential over long-term performance, affecting their resilience to climate variability.

Transient amplification enhances the persistence of tropicalising coral populations in marginal high latitude environments.

The paper shows that transient demographic characteristics, like resistance and recovery, help subtropical corals expand poleward in high latitude environments.

Gene flux and acid-imposed selection are the main drivers of antimicrobial resistance in broiler chicks infected with Salmonella enterica serovar Heidelberg

This study shows that antibiotic-resistant Salmonella can acquire resistance from gut commensals in antibiotic-free broiler chicks, driven by horizontal gene transfer and acidic selection pressure, suggesting antibiotic reduction alone may not limit resistance spread.

Regulatory T cell expansion by a highly CD25-dependent IL-2 mutein arrests ongoing autoimmunity

A CD25-dependent IL-2 mutein selectively expands regulatory T cells and provides potent and targeted control of autoimmunity.

Designing an occupancy framework to monitor an endemic rainforest duck: Methodological and modelling considerations

The paper conducts occupancy surveys of a rare duck species to assess habitat factors influencing its presence and recommends future research strategies.

Evaluation of Reproducible and Transparent Research Practices in Pulmonology

This study evaluates reproducibility in pulmonology research, finding low availability of materials, protocols, and analysis scripts.

Dynamics between horizontal gene transfer and acquired antibiotic resistance in S. Heidelberg following in vitro incubation in broiler ceca

This study shows that S. Heidelberg can acquire antibiotic resistance plasmids from broiler ceca microbiota in vitro, highlighting gene transfer dynamics in the gut.

Hotspot mutations and ColE1 plasmids contribute to the fitness of Salmonella Heidelberg in poultry litter

This study shows that plasmids and hotspot mutations enhance the survival of S. Heidelberg in poultry litter by increasing fitness and antibiotic resistance.