Author

M. N. Pham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:human· 1

Frequent Co-Authors

N. P. King· 5 shared A. C. Walls· 4 shared B. Fiala· 4 shared E. Kepl· 4 shared L. Carter· 4 shared A. Blackstone· 3 shared C. Ogohara· 3 shared C. Sydeman· 3 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

N. P. King

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Combinatorial immune refocusing within the influenza hemagglutinin head elicits cross-neutralizing antibody responses

A. Dosey, D. Ellis, S. Boyoglu-Barnum, H. Syeda, M. Saunders, M. Watson, J. C. Kraft, M. N. Pham, M. Guttman, K. K. Lee, M. Kanekiyo, N. P. King

This study evaluates trihead nanoparticle immunogens to enhance cross-neutralizing antibody responses against influenza H1 viruses by combining immunofocusing techniques.

bioRxiv · May 23, 2023 · PreprintImmunology

Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice

A. C. Walls, L. A. VanBlargan, K. Wu, A. Choi, M. J. Navarro, D. Lee, L. Avena, D. M. Berrueta, M. N. Pham, S. Elbashir, M. C. Miranda, E. Kepl, M. Johnson, A. Blackstone, K. R. Sprouse, , D. Veesler

This study compares neutralizing antibody responses to SARS-CoV-2 variants in vaccinated humans and mice, finding that mice do not accurately reflect the breadth and potency seen in humans.

bioRxiv · Feb 7, 2022Immunology

Stabilization of the SARS-CoV-2 Spike receptor-binding domain using deep mutational scanning and structure-based design

D. Ellis, N. Brunette, K. H. D. Crawford, A. C. Walls, M. N. Pham, C. Chen, K.-L. Herpoldt, B. Fiala, M. Murphy, D. Pettie, J. C. Kraft, K. D. Malone, M. J. Navarro, C. Ogohara, E. Kepl, , N. P. King

This paper designs stabilized SARS-CoV-2 RBD variants using deep mutational scanning and structure-based design, showing improved thermal stability and manufacturability for vaccine applications.

bioRxiv · May 15, 2021Microbiology

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

A. C. Walls, M. C. Miranda, M. N. Pham, A. Schaefer, A. Greaney, P. S. Arunachalam, M.-J. Navarro, M. A. Tortorici, K. Rogers, M. A. O'Connor, L. Shireff, D. E. Ferrell, N. Brunette, E. Kepl, J. E. Bowen, , Veesler

This study shows that a SARS-CoV-2 RBD nanoparticle vaccine protects against SARS-CoV-2 and related sarbecoviruses, including variants, in mice and non-human primates.

bioRxiv · Mar 15, 2021Immunology

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

A. C. Walls, B. Fiala, A. Schaefer, S. Wrenn, M. N. Pham, M. Murphy, L. V. Tse, L. Shehata, M. A. O'Connor, C. Chen, M. J. Navarro, M. C. Miranda, D. Pettie, R. Ravichandran, J. C. Kraft, , N. P. King

This study designs SARS-CoV-2 nanoparticle vaccines that induce strong neutralizing antibodies in mice, with higher titers and lower doses than existing trimer vaccines.

bioRxiv · Aug 11, 2020Immunology

Regulatory T cell expansion by a highly CD25-dependent IL-2 mutein arrests ongoing autoimmunity

L. Khoryati, M. N. Pham, M. Sherve, S. Kumari, K. Cook, J. Pearson, M. Bogdani, D. J. Campbell, M. A. Gavin

A CD25-dependent IL-2 mutein selectively expands regulatory T cells and provides potent and targeted control of autoimmunity.

bioRxiv · May 10, 2020 · PreprintImmunology