K. Curtius

Estimating single cell clonal dynamics in human blood using coalescent theory

This paper estimates the net growth rate of hematopoietic clones in human blood using coalescent theory, finding that clones with multiple driver mutations grow faster and are linked to earlier MPN diagnosis.

AI-assisted Discovery of an Ethnicity-influenced Driver of Cell Transformation in Esophageal and Gastroesophageal Junction Adenocarcinomas

The paper uses AI to identify a racially influenced immune driver of esophageal and gastroesophageal junction adenocarcinomas, showing its absence in African Americans and association with neutrophil processes and genetic variants.

Autoimmune Alleles at the Major Histocompatibility Locus Modify Melanoma Susceptibility

This study shows that MHC-I autoimmune alleles are associated with reduced melanoma risk and later diagnosis age, independent of existing polygenic risk scores.

Barrett's esophagus is the precursor of all esophageal adenocarcinomas

This study uses a computational model to show that all esophageal adenocarcinoma cases in the US can be explained by Barrett's esophagus, both diagnosed and undiagnosed, supporting targeted screening efforts.

Optimal timing for cancer screening and adaptive surveillance using mathematical modeling

This paper uses mathematical modeling to optimize cancer screening timing and adaptive surveillance, finding optimal screening ages for Barrett's esophagus patients older than current recommendations.

Mechanisms of Chromosomal Instability in High-grade Serous Ovarian Carcinoma.

This study identifies multiple co-existing mechanisms driving chromosomal instability in high-grade serous ovarian carcinoma using functional assays and cell line models.