Author

M. Pagadala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:gene regulatory network inference· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 3 Assay:whole-genome sequencing· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

H. Carter· 5 shared A. Castro· 3 shared J. P. Mesirov· 2 shared J. Talwar· 2 shared M. Zanetti· 2 shared W. K. Thompson· 2 shared A. Protheroe· 1 shared A. Ryan· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersCancer Biology

H. Carter

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5 papers

Recent·Most cited

Integrated germline and somatic features reveal divergent immune pathways driving ICB response

T. J. Sears, M. Pagadala, A. Castro, K.-H. Lee, J. Kong, K. Tanaka, S. Lippman, M. J. Zanetti, H. Carter

This paper uses machine learning to predict ICB response by integrating germline and somatic features, revealing differences in immune pathways and clinical outcomes between MHC-I and MHC-II neoantigen reliant tumors.

bioRxiv · Jan 12, 2024 · PreprintCancer Biology

The landscape of extrachromosomal circular DNA in medulloblastoma

O. S. Chapman, J. Luebeck, S. Wani, A. Tiwari, M. Pagadala, S. Wang, J. D. Larson, J. T. Lange, I. T.-L. Wong, S. R. Dehkordi, S. Chandran, M. Adam, Y. Lin, E. Juarez, J. T. Robinson, , L. Chavez

This study identifies ecDNA in 18% of medulloblastoma patients, linking it to higher relapse and mortality rates and suggesting enhancer rewiring as an oncogenic mechanism.

bioRxiv · Oct 18, 2021 · PreprintCancer Biology

Autoimmune Alleles at the Major Histocompatibility Locus Modify Melanoma Susceptibility

J. Talwar, D. Laub, M. Pagadala, A. Castro, M. Lewis, G. E. Luebeck, B. Gorman, C. Pan, F. N. Dong, K. Markianos, R. Hauger, S. Pyarajan, P. S. Tsao, G. P. Morris, R. M. Salem, , H. Carter

This study shows that MHC-I autoimmune alleles are associated with reduced melanoma risk and later diagnosis age, independent of existing polygenic risk scores.

bioRxiv · Aug 12, 2021Cancer Biology

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

M. Pagadala, V. H. Wu, E. Perez-Guijarro, H. Kim, A. Castro, J. Talwar, T. Sears, C. Gonzalez-Colin, S. Cao, B. Schmiedel, S. Goudarzi, D. Kirani, R. Salem, G. Morris, O. Harismendy, , H. Carter

The paper identifies germline variants associated with the tumor immune microenvironment, linking them to cancer risk and immunotherapy response.

bioRxiv · Apr 14, 2021 · PreprintCancer Biology

Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression and drug response

P. Zhang, I. Kitchen-Smith, L. Xiong, G. Stracquadanio, K. Brown, P. Richter, M. Wallace, E. Bond, N. Sahgal, S. Moore, S. Nornes, S. De Val, M. Surakhy, D. Sims, X. Wang, , G. Bond

The paper investigates interactions between germline and somatic variants in the p53 pathway to show their combined effects on cancer risk, progression, and treatment response.

bioRxiv · Nov 9, 2019Cancer Biology