N. Tamura

Organelle landscape analysis using a multi-parametric particle-based method

The paper introduces a multi-parametric particle-based method to analyze organelle landscapes, enabling visualization of heterogeneous organelle structures and transitional states using fluorescence microscopy and UMAP.

Comprehensive analysis of autophagic functions of WIPI family proteins and their implications for the pathogenesis of β-propeller associated neurodegeneration

This study investigates the roles of WIPI proteins in autophagy and their implications in β-propeller associated neurodegeneration, finding that WIPI2 is essential for autophagy and that some BPAN-related mutations affect autophagic activity.

Membrane tethering potency of Rab-family small GTPases is defined by the C-terminal hypervariable regions

This study shows that the C-terminal hypervariable regions (HVRs) of Rab-family GTPases regulate their membrane tethering potency by controlling the attachment of the G-domain to membranes.

Mechanisms of Chromosomal Instability in High-grade Serous Ovarian Carcinoma.

This study identifies multiple co-existing mechanisms driving chromosomal instability in high-grade serous ovarian carcinoma using functional assays and cell line models.

Homotypic and heterotypic trans-assembly of human Rab-family small GTPases in reconstituted membrane tethering

This study investigates how human Rab-family GTPases mediate membrane tethering through homotypic and heterotypic trans-assembly in a reconstituted system, revealing their specific and synergistic roles.

Non-Random Mis-Segregation of Human Chromosomes.

The paper shows that human chromosome mis-segregation is non-random, with specific chromosomes showing higher rates of aneuploidy due to cohesion fatigue.