p66Shc is an apoptotic rheostat whose targeted ROS inhibition improves MI outcomes
L. Haslem, J. M. Hays, H. Schmitz, S. Matsuzaki, V. Sjoelund, S. D. Byrum, K. M. A. Humphries, J. K. Frazer, B. Demeler, D. M. Benbrook, R. M. Tierney, K. D. Duggan, F. A. Hays
This study identifies p66Shc as a stress-dependent apoptotic rheostat and shows that reducing its pro-apoptotic ROS production improves myocardial infarction outcomes in zebrafish.
bioRxiv · Apr 14, 2022 · PreprintBiochemistry