Author

J. K. Frazer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:zebrafish· 4 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Borga· 2 shared C. Foster· 2 shared G. Park· 2 shared A. Hasan· 1 shared B. Demeler· 1 shared C. A. Foster· 1 shared D. Langenau· 1 shared D. M. Benbrook· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

C. Borga

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Diverse Epithelial Lymphocytes in Zebrafish Revealed Using a Novel Scale Biopsy Method

G. Park, C. A. Foster, M. Malone-Perez, A. Hasan, J. J. Macias, J. K. Frazer

This paper introduces a novel biopsy method to study zebrafish epidermal lymphocytes, revealing diverse cell types and their gene expression profiles.

bioRxiv · Aug 9, 2023Immunology

p66Shc is an apoptotic rheostat whose targeted ROS inhibition improves MI outcomes

L. Haslem, J. M. Hays, H. Schmitz, S. Matsuzaki, V. Sjoelund, S. D. Byrum, K. M. A. Humphries, J. K. Frazer, B. Demeler, D. M. Benbrook, R. M. Tierney, K. D. Duggan, F. A. Hays

This study identifies p66Shc as a stress-dependent apoptotic rheostat and shows that reducing its pro-apoptotic ROS production improves myocardial infarction outcomes in zebrafish.

bioRxiv · Apr 14, 2022 · PreprintBiochemistry

Molecularly distinct models of zebrafish Myc-induced B cell leukemia

C. Borga, C. Foster, S. Iyer, S. Garcia, D. Langenau, J. K. Frazer

The paper compares two zebrafish B cell leukemia models driven by murine or human c-MYC, finding distinct lineage origins and molecular pathway signatures.

bioRxiv · Nov 6, 2018Cancer Biology

Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis

C. Borga, G. Park, C. Foster, J. Burroughs-Garcia, M. Marchesin, S. T. Ahmed, S. Bresolin, L. Batchelor, T. Scordino, R. R. Miles, G. te Kronnie, J. L. Regens, J. K. Frazer

This paper establishes the first zebrafish pre-B ALL model driven by human MYC, which also develops T-ALL, revealing differences in leukemogenesis and offering therapeutic insights.

bioRxiv · Mar 13, 2018Cancer Biology