Author

K. E. Leigh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell type annotation· 1 Organism:human· 1

Frequent Co-Authors

Y. Modis· 3 shared A. C. Borgeaud· 1 shared A. Herrero del Valle· 1 shared B. J. Ferguson· 1 shared C. E. Bryant· 1 shared C. Heroven· 1 shared D. Albrecht· 1 shared H. Alemayehu· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

Y. Modis

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Contrasting functions of ATP hydrolysis by MDA5 and LGP2 in viral RNA sensing

R. Singh, Y. Wu, A. Herrero del Valle, K. E. Leigh, M. T. K. Cheng, B. J. Ferguson, Y. Modis

This study investigates how ATP hydrolysis by MDA5 and LGP2 influences viral RNA sensing, showing MDA5's selectivity and LGP2's role in modulating MDA5 filament assembly.

bioRxiv · May 25, 2023Biochemistry

The Vaccinia virus chondroitin sulfate binding protein drives host membrane curvature to facilitate fusion

L. Pokorny, J. J. Burden, D. Albrecht, R. Bamford, K. E. Leigh, P. Sridhar, T. J. Knowles, Y. Modis, J. Mercer

This study shows that the vaccinia virus D8 protein drives host membrane curvature to facilitate fusion by guiding virion binding orientation and promoting membrane invagination.

bioRxiv · Mar 10, 2022Microbiology

Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization

Y. Liu, H. Zhai, H. Alemayehu, J. Boulanger, L. J. Hopkins, A. C. Borgeaud, C. Heroven, J. D. Howe, K. E. Leigh, C. E. Bryant, Y. Modis

The paper uses cryo-electron tomography to reveal the ultrastructure of ASC specks and gasdermin D pores in NLRP3-activated cells.

bioRxiv · Sep 20, 2021Immunology