Author

T. J. Knowles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Organism:E. coli· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

P. Sridhar· 3 shared J. A. Bryant· 2 shared M. Banzhaf· 2 shared A. Colyer· 1 shared A. F. Cunningham· 1 shared A. Rossiter· 1 shared A. Teo· 1 shared C. D. Neilson· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

P. Sridhar

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Genome-wide synthetic-lethality screen of Bam complex associated genes in Escherichia coli

J. A. Bryant, K. A. Staunton, H. M. Doherty, M. B. Alao, X. Ma, J. Morcinek-Orlowska, E. C. A. Goodall, J. Gray, M. Milner, L. Kidger, C. D. Neilson, J. A. Cole, F. de Cogan, T. J. Knowles, M. K. Glinkowska, , M. Banzhaf

The paper identifies synthetic-lethal interactions of Bam complex associated genes in E. coli, revealing dependencies on lipid composition and peptidoglycan synthesis.

bioRxiv · Jul 5, 2023Microbiology

Peptidoglycan maturation controls spatiotemporal organisation of outer membrane proteins in Escherichia coli

G. Mamou, F. Corona, R. Cohen-Khait, D. Sun, P. Sridhar, M. Pazos, T. J. Knowles, C. Kleanthous, W. Vollmer

The paper shows that peptidoglycan maturation regulates the spatiotemporal organization of outer membrane proteins in E. coli by modulating BAM activity and OMP insertion.

bioRxiv · Apr 11, 2022 · PreprintMicrobiology

The Vaccinia virus chondroitin sulfate binding protein drives host membrane curvature to facilitate fusion

L. Pokorny, J. J. Burden, D. Albrecht, R. Bamford, K. E. Leigh, P. Sridhar, T. J. Knowles, Y. Modis, J. Mercer

This study shows that the vaccinia virus D8 protein drives host membrane curvature to facilitate fusion by guiding virion binding orientation and promoting membrane invagination.

bioRxiv · Mar 10, 2022Microbiology

Structure-function analyses of dual-BON domain protein DolP identifies phospholipid binding as a new mechanism for protein localisation

J. A. Bryant, F. Morris, T. J. Knowles, R. Maderbocus, E. Heinz, G. Boelter, D. Alodaini, A. Colyer, P. wotherspoon, K. Staunton, M. Jeeves, D. Browning, Y. Sevastsyanovich, T. Wells, A. Rossiter, , i. henderson

This study identifies phospholipid binding as a mechanism for DolP localization, revealing its structure and function in Gram-negative bacteria.

bioRxiv · Aug 10, 2020 · PreprintBiochemistry