Author

J. D. Howe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

A. C. Borgeaud· 1 shared A. J. Thompson· 1 shared C. E. Bryant· 1 shared C. Heroven· 1 shared D. S. Alonzi· 1 shared G. J. Davies· 1 shared H. Alemayehu· 1 shared H. Zhai· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

A. C. Borgeaud

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization

Y. Liu, H. Zhai, H. Alemayehu, J. Boulanger, L. J. Hopkins, A. C. Borgeaud, C. Heroven, J. D. Howe, K. E. Leigh, C. E. Bryant, Y. Modis

The paper uses cryo-electron tomography to reveal the ultrastructure of ASC specks and gasdermin D pores in NLRP3-activated cells.

bioRxiv · Sep 20, 2021Immunology

Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target

L. F. Sobala, P. Z. Fernandes, Z. Hakki, A. J. Thompson, J. D. Howe, M. Hill, N. Zitzmann, S. Davies, Z. Stamataki, T. D. Butters, D. S. Alonzi, S. J. Williams, G. J. Davies

The paper reports the structure of human MANEA and inhibitor complexes, revealing its mechanism and informing the development of antiviral agents against bovine viral diarrhea and dengue viruses.

bioRxiv · Jun 30, 2020Biochemistry