N4-Hydroxycytidine/Molnupiravir Inhibits RNA-Virus Induced Encephalitis by Producing Mutated Viruses with Reduced Fitness
D. Ojha, C. S. Hill, S. Zhou, A. B. Evans, J. M. Leung, C. S. Lewis, F. Amblard, R. F. Schinazi, R. S. Baric, K. E. Peterson, R. Swanstrom
This study shows that N4-hydroxycytidine and its prodrug molnupiravir reduce RNA-virus-induced encephalitis by producing less fit viruses with G-to-A and C-to-U mutations.
bioRxiv · Aug 22, 2023 · PreprintMicrobiology