Author

J. M. Leung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 3 Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Research Focus:differential expression· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

J. Liu· 3 shared K. Hu· 3 shared A. Cronkite· 2 shared A. L. Graham· 2 shared C. Drake-Dunn· 2 shared C. Hansen· 2 shared C. McCauley· 2 shared E. Nagayasu· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

J. Liu

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

N4-Hydroxycytidine/Molnupiravir Inhibits RNA-Virus Induced Encephalitis by Producing Mutated Viruses with Reduced Fitness

D. Ojha, C. S. Hill, S. Zhou, A. B. Evans, J. M. Leung, C. S. Lewis, F. Amblard, R. F. Schinazi, R. S. Baric, K. E. Peterson, R. Swanstrom

This study shows that N4-hydroxycytidine and its prodrug molnupiravir reduce RNA-virus-induced encephalitis by producing less fit viruses with G-to-A and C-to-U mutations.

bioRxiv · Aug 22, 2023 · PreprintMicrobiology

LPATH: A semi-automated Python tool for clustering molecular pathways

A. Bogetti, J. M. Leung, L. Chong

The paper introduces LPATH, a Python tool for clustering molecular pathways using linguistics-assisted methods, demonstrating its effectiveness on alanine dipeptide conformational transitions.

bioRxiv · Aug 17, 2023 · PreprintBiophysics

Multi-omic Profiling Reveals Early Immunological Indicators for Identifying COVID-19 Progressors

K. A. Drake, D. Talantov, G. Tong, J. T. Lin, S. Verheijden, S. Katz, J. M. Leung, B. Yuen, V. Krishna, M. J. Wu, A. Sutherland, S. Short, P. Kheradpour, M. R. Mumbach, K. M. Franz, , The PRESCO Study Group

The paper identifies early immunological indicators of severe COVID-19 by analyzing multi-omic data from the immediate post-diagnosis phase.

bioRxiv · May 25, 2023Immunology

Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19

S. Robertson, O. Bedard, K. McNally, C. Shaia, C. Clancy, M. Lewis, R. Broeckel, A. Chiramel, J. G. Shannon, G. Sturdevant, R. Rosenke, S. L. Anzick, E. Forte, C. Preuss, C. Baker, , S. Best

The paper uses genetically diverse mice to model varied innate immune responses to SARS-CoV-2 infection, showing differences in survival, viral replication, and cytokine profiles.

bioRxiv · Sep 17, 2021Microbiology

A doublecortin-domain protein of Toxoplasma and its orthologues bind to and modify the structure and organization of tubulin polymers

J. M. Leung, E. Nagayasu, Y.-C. Hwang, J. Liu, P. Pierce, I. Q. Phan, R. A. Prentice, J. M. Murray, K. Hu

This study identifies TgDCX, a Toxoplasma protein that binds and modifies tubulin polymers, enabling curved structures critical for parasite invasion.

bioRxiv · Jan 15, 2020Cell Biology

Housing laboratory mice deficient for Nod2 and Atg16l1 in a natural environment uncovers genetic and environmental contributions to immune variation.

J.-D. Lin, J. C. Devlin, F. Yeung, C. McCauley, J. M. Leung, Y.-H. Chen, A. Cronkite, C. Hansen, C. Drake-Dunn, K. V. Ruggles, K. Cadwell, A. L. Graham, P. Loke

Exposing mice with genetic mutations to a natural environment reveals environmental effects on immune cell populations and genetic effects on cytokine responses.

bioRxiv · Dec 9, 2019Immunology

Altered immunity of laboratory mice in the natural environment is associated with fungal colonization

F. Yeung, Y.-H. Chen, J.-D. Lin, J. M. Leung, C. McCauley, J. C. Devlin, C. Hansen, A. Cronkite, Z. W. Stephens, C. Drake-Dunn, K. V. Ruggles, J. L. Round, P. Loke, A. L. Graham, K. Cadwell

This study shows that rewilding laboratory mice in an outdoor environment alters their immune system, increasing granulocytes and changing microbiota, but not causing infection from known pathogens.

bioRxiv · Dec 9, 2019Immunology

TgCentrin2 is required for invasion and replication in the human parasite Toxoplasma gondii

J. M. Leung, J. Liu, L. A. Wetzel, K. Hu

This study identifies TgCentrin2's role in Toxoplasma gondii by showing its necessity for invasion and replication through functional characterization.

bioRxiv · Jun 1, 2019Cell Biology

Stability and function of a putative microtubule organizing center in the human parasite Toxoplasma gondii

J. M. Leung, Y. He, F. Zhang, Y.-C. Hwang, E. Nagayasu, J. Liu, J. M. Murray, K. Hu

This study investigates the role of the apical polar ring in Toxoplasma gondii by analyzing KinesinA and APR1, showing its structural importance for microtubule organization and parasite function.

bioRxiv · Mar 14, 2017Cell Biology