S. Horvath

A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan

This study shows that inducing a torpor-like state in mice slows blood epigenetic aging and improves healthspan by reducing core body temperature.

MYB68 orchestrates cork differentiation by regulating stem cell proliferation and suberin deposition

This study identifies MYB36 subclade transcription factors as regulators of cork differentiation by promoting suberin deposition and repressing cork cambium proliferation.

Epigenetic predictors of species maximum lifespan and other life history traits in mammals

The paper develops DNA methylation predictors for mammalian maximum lifespan, gestation time, and sexual maturity, showing species-level epigenetic signatures that differ from individual lifespan variation.

Cellular Allostatic Load is linked to Increased Energy Expenditure and Accelerated Biological Aging

The paper shows chronic glucocorticoid exposure increases cellular energy expenditure and accelerates aging in human fibroblasts.

Fundamental equations linking methylation dynamics to maximum lifespan in mammals

This study links methylation dynamics to maximum lifespan in mammals by showing a reciprocal relationship between methylation change rates and lifespan across species.

Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging.

The paper uses partial cellular reprogramming to reduce DNA damage in an ERCC1 mouse model of premature aging, showing restoration of the epigenetic clock and DNA repair processes.

Increased hyaluronan by naked mole-rat HAS2 extends lifespan in mice

This study shows that overexpressing the naked mole-rat HAS2 gene in mice increases hyaluronan levels, reduces inflammation, and extends lifespan and healthspan.

Divergent age-related methylation patterns in long and short-lived mammals

The paper identifies CpGs with divergent age-related methylation patterns in long and short-lived mammals and develops epigenetic clocks based on these CpGs.

OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases

The paper shows that OxPhos dysfunction leads to hypermetabolism and reduced lifespan in cells and mitochondrial disease patients.

A Multi-Omics and Bioenergetics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations

The paper presents a longitudinal multi-omics dataset of human fibroblasts with mitochondrial perturbations to study aging mechanisms and bioenergetics.

Multi-omic rejuvenation and lifespan extension upon exposure to youthful circulation

This study shows that prolonged heterochronic parabiosis reduces biological age and extends lifespan in mice through long-term epigenetic and transcriptomic changes.

Epigenetic clock and methylation studies in gray short-tailed opossums

The paper generates DNA methylation data from opossum tissues and develops epigenetic clocks for opossums and dual-species human-opossum clocks to measure age.

Small extracellular vesicles from young mice prevent frailty, improve healthspan and decrease epigenetic age in old mice.

DNA Methylation Networks Underlying Mammalian Traits

This study analyzes DNA methylation across 11,117 samples from 176 species to identify modules related to traits like age, lifespan, and phylogeny, revealing epigenetic patterns across evolution and aging.

Hibernation slows epigenetic aging in yellow-bellied marmots

This study examines how hibernation affects epigenetic aging in yellow-bellied marmots using epigenetic clocks and pacemakers, finding that aging slows during hibernation.

The analysis of epigenomic evolution

The paper applies phylogenetic methods to epigenetic data, showing DNA methylation conservation and its correlation with transcription factor binding density in great apes.

Epigenetic clock and DNA methylation studies of roe deer in the wild

This study develops epigenetic clocks for roe deer to assess how environment and sex influence DNA methylation aging in wild populations.

Human Aging DNA Methylation Signatures are Conserved but Accelerated in Cultured Fibroblasts

Transient non-integrative nuclear reprogramming promotes multifaceted reversal of aging in human cells

This study shows that transient non-integrative nuclear reprogramming reverses aging in human cells by rejuvenating epigenetic clocks and cellular functions without losing identity.