Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2
N. P. Azouz, A. M. Klingler, V. Callahan, I. V. Akhrymuk, K. Elez, L. Raich, B. M. Henry, J. L. Benoit, S. W. Benoit, F. Noe, K. Kehn-Hall, M. E. Rothenberg
This study identifies alpha 1 antitrypsin (A1AT) as a TMPRSS2 inhibitor that limits SARS-CoV-2 dissemination by inhibiting extracellular proteases involved in viral entry.
bioRxiv · May 4, 2020Microbiology