N. P. Azouz

Aryl hydrocarbon receptor (AHR) and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis

This study identifies AHR's role in modulating IL-13 signaling in AD keratinocytes through direct transcriptional regulation.

Aryl Hydrocarbon Receptor Suppresses Eosinophilic Esophagitis Responses through OVOL1 and SPINK7

This study identifies OVOL1 as a regulator of SPINK7 expression in eosinophilic esophagitis, showing AHR activation enhances SPINK7 and barrier function while IL-4 and IL-13 inhibit this pathway.

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

This paper identifies a novel class of TMPRSS2 inhibitors that effectively block SARS-CoV-2 and MERS-CoV entry and show promise as a therapeutic for COVID-19.

Molecular mechanism of SARS-CoV-2 cell entry inhibition via TMPRSS2 by Camostat and Nafamostat mesylate

This study investigates how camostat and nafamostat inhibit SARS-CoV-2 entry by targeting TMPRSS2 through molecular simulations and experiments, showing nafamostat's higher efficacy due to increased Michaelis complex binding.

Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2

This study identifies alpha 1 antitrypsin (A1AT) as a TMPRSS2 inhibitor that limits SARS-CoV-2 dissemination by inhibiting extracellular proteases involved in viral entry.