Author

M. E. Rothenberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Research Focus:cell type annotation· 4 Approach:statistical model· 4 Approach:deep learning· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2

Frequent Co-Authors

N. P. Azouz· 5 shared A. M. Klingler· 3 shared A. T. Dwyer· 2 shared F. Noe· 2 shared J. M. Caldwell· 2 shared L. Raich· 2 shared M. Rochman· 2 shared A. Appiagyei· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersImmunology

N. P. Azouz

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Machine Learning Based Identification and Characterization of Mast Cells in Eosinophilic Esophagitis

S. Zhang, J. M. Caldwell, M. Rochman, M. H. Collins, M. E. Rothenberg

This paper uses machine learning to identify and characterize mast cells in eosinophilic esophagitis, finding spatially distinct populations and correlations with disease features.

bioRxiv · Oct 25, 2023Immunology

Aryl hydrocarbon receptor (AHR) and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis

S. P. Proper, A. T. Dwyer, A. Appiagyei, J. M. Felton, N. Ben-Baruch Morgenstern, J. M. Marlman, M. Kotliar, A. Barski, T. D. Troutman, M. E. Rothenberg, T. B. Mersha, N. P. Azouz

This study identifies AHR's role in modulating IL-13 signaling in AD keratinocytes through direct transcriptional regulation.

bioRxiv · Jun 17, 2023Immunology

Aryl Hydrocarbon Receptor Suppresses Eosinophilic Esophagitis Responses through OVOL1 and SPINK7

N. P. Azouz, A. M. Klingler, M. Rochman, M. Paul, J. M. Caldwell, M. Brusilovsky, A. T. Dwyer, X. P. Chen, D. Miller, A. Lynch, C. Forney, L. Kottyan, M. T. Weirauch, M. E. Rothenberg

This study identifies OVOL1 as a regulator of SPINK7 expression in eosinophilic esophagitis, showing AHR activation enhances SPINK7 and barrier function while IL-4 and IL-13 inhibit this pathway.

bioRxiv · May 17, 2023 · PreprintImmunology

Implicating Gene and Cell Networks Responsible for Differential COVID-19 Host Responses via an Interactive Single Cell Web Portal

K. Jin, E. E. Bardes, A. Mitelpunkt, Y. J. Wang, S. Bhatnagar, S. Sengupta, D. P. Krummel, M. E. Rothenberg, B. J. Aronow

The paper creates a web portal to compare single-cell transcriptome data from COVID-19 and control samples, identifying gene and cell network hypotheses related to differential host responses.

bioRxiv · Jun 7, 2021Immunology

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

M. Mahoney, V. C. Damalanka, M. Tartell, D. H. Chung, A. L. Lourenco, D. Pwee, A. E. Mayer Bridwell, M. Hoffmann, J. Voss, P. Karmakar, N. P. Azouz, A. M. Klinger, P. W. Rothlauf, C. E. Thompson, M. Lee, , J. W. Janetka

This paper identifies a novel class of TMPRSS2 inhibitors that effectively block SARS-CoV-2 and MERS-CoV entry and show promise as a therapeutic for COVID-19.

bioRxiv · May 6, 2021Microbiology

Molecular mechanism of SARS-CoV-2 cell entry inhibition via TMPRSS2 by Camostat and Nafamostat mesylate

T. Hempel, L. Raich, S. Olsson, N. P. Azouz, A. M. Klingler, M. E. Rothenberg, F. Noe

This study investigates how camostat and nafamostat inhibit SARS-CoV-2 entry by targeting TMPRSS2 through molecular simulations and experiments, showing nafamostat's higher efficacy due to increased Michaelis complex binding.

Chemical Science · Jan 1, 2021Peer-reviewedBiophysics

Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2

N. P. Azouz, A. M. Klingler, V. Callahan, I. V. Akhrymuk, K. Elez, L. Raich, B. M. Henry, J. L. Benoit, S. W. Benoit, F. Noe, K. Kehn-Hall, M. E. Rothenberg

This study identifies alpha 1 antitrypsin (A1AT) as a TMPRSS2 inhibitor that limits SARS-CoV-2 dissemination by inhibiting extracellular proteases involved in viral entry.

bioRxiv · May 4, 2020Microbiology