Author

K. Kehn-Hall

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Lehman· 2 shared I. Akhrymuk· 2 shared I. V. Akhrymuk· 2 shared V. Callahan· 2 shared A. A. Waheed· 1 shared A. A. Zinn· 1 shared A. M. Klingler· 1 shared A. Munns· 1 shared

Activity by Year

2020-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

C. Lehman

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

RK-33, a small molecule inhibitor of host RNA helicase DDX3, suppresses multiple variants of SARS-CoV-2

F. Vesuna, I. Akhrymuk, A. Smith, P. T. Winnard, S.-C. Lin, R. Scharpf, K. Kehn-Hall, V. Raman

This study shows that RK-33, a DDX3 inhibitor, reduces SARS-CoV-2 viral load across multiple variants in Calu-3 cells and downregulates SARS-CoV-2 genes and TMPRSS2 expression.

bioRxiv · Feb 28, 2022Microbiology

Rapidly self-sterilizing PPE capable of 99.9% SARS-CoV-2 deactivation in 30 seconds

A. A. Zinn, M. Izadjoo, H. Kim, K. Kehn-Hall, C. Lehman, R. L. Brody, R. R. Roth, A. Vega, K. K. Nguyen, N. T. Ngo, H. T. Zinn, L. Panny, R. Flor, N. Antonopoulos, R. M. Stoltenberg

This paper introduces a self-sterilizing PPE material that deactivates SARS-CoV-2 in 30 seconds, outperforming conventional copper configurations.

bioRxiv · Nov 16, 2020 · PreprintImmunology

Silicon Nitride Inactivates SARS-CoV-2 in vitro

C. W. Lehman, R. Flur, K. Kehn-Hall, B. J. McEntire, B. S. Bal, R. M. Bock

This study shows that silicon nitride inactivates SARS-CoV-2 in vitro without harming Vero cells, with higher concentrations and longer exposure times leading to greater viral reduction.

bioRxiv · Aug 29, 2020 · PreprintMicrobiology

Nanotrap(R) particles improve detection of SARS-CoV-2 for pooled sample methods, extraction-free saliva methods, and extraction-free medium methods

R. A. Barclay, I. Akhrymuk, A. Patnaik, V. Callahan, C. Lehman, P. Andersen, R. Barbero, S. Barksdale, R. Dunlap, D. Goldfarb, T. Jones-Roe, R. Kelly, B. Kim, S. Miao, A. Munns, , B. Lepene

This paper introduces a method using Nanotrap(R) particles to improve SARS-CoV-2 detection in pooled samples, saliva, and transport medium by concentrating virus before RNA extraction.

bioRxiv · Jun 25, 2020 · PreprintMicrobiology

Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2

N. P. Azouz, A. M. Klingler, V. Callahan, I. V. Akhrymuk, K. Elez, L. Raich, B. M. Henry, J. L. Benoit, S. W. Benoit, F. Noe, K. Kehn-Hall, M. E. Rothenberg

This study identifies alpha 1 antitrypsin (A1AT) as a TMPRSS2 inhibitor that limits SARS-CoV-2 dissemination by inhibiting extracellular proteases involved in viral entry.

bioRxiv · May 4, 2020Microbiology

PSGL-1 inhibits the virion incorporation of SARS-CoV and SARS-CoV-2 spike glycoproteins and impairs virus attachment and infectivity

S. He, A. A. Waheed, B. Hetrick, D. Dabbagh, I. V. Akhrymuk, K. Kehn-Hall, E. O. Freed, Y. Wu

The paper shows PSGL-1 inhibits SARS-CoV and SARS-CoV-2 spike glycoprotein incorporation into pseudovirions, blocking virus attachment and infectivity.

bioRxiv · May 1, 2020 · PreprintMicrobiology