Author

A. M. Klingler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

M. E. Rothenberg· 3 shared N. P. Azouz· 3 shared F. Noe· 2 shared L. Raich· 2 shared A. Lynch· 1 shared A. T. Dwyer· 1 shared B. M. Henry· 1 shared C. Forney· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

M. E. Rothenberg

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Author profile →

3 papers

Recent·Most cited

Aryl Hydrocarbon Receptor Suppresses Eosinophilic Esophagitis Responses through OVOL1 and SPINK7

N. P. Azouz, A. M. Klingler, M. Rochman, M. Paul, J. M. Caldwell, M. Brusilovsky, A. T. Dwyer, X. P. Chen, D. Miller, A. Lynch, C. Forney, L. Kottyan, M. T. Weirauch, M. E. Rothenberg

This study identifies OVOL1 as a regulator of SPINK7 expression in eosinophilic esophagitis, showing AHR activation enhances SPINK7 and barrier function while IL-4 and IL-13 inhibit this pathway.

bioRxiv · May 17, 2023 · PreprintImmunology

Molecular mechanism of SARS-CoV-2 cell entry inhibition via TMPRSS2 by Camostat and Nafamostat mesylate

T. Hempel, L. Raich, S. Olsson, N. P. Azouz, A. M. Klingler, M. E. Rothenberg, F. Noe

This study investigates how camostat and nafamostat inhibit SARS-CoV-2 entry by targeting TMPRSS2 through molecular simulations and experiments, showing nafamostat's higher efficacy due to increased Michaelis complex binding.

Chemical Science · Jan 1, 2021Peer-reviewedBiophysics

Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2

N. P. Azouz, A. M. Klingler, V. Callahan, I. V. Akhrymuk, K. Elez, L. Raich, B. M. Henry, J. L. Benoit, S. W. Benoit, F. Noe, K. Kehn-Hall, M. E. Rothenberg

This study identifies alpha 1 antitrypsin (A1AT) as a TMPRSS2 inhibitor that limits SARS-CoV-2 dissemination by inhibiting extracellular proteases involved in viral entry.

bioRxiv · May 4, 2020Microbiology