K. H. Biswas

A Slow but Steady NanoLuc: R162A mutation results in a decreased, but stable, NanoLuc activity

This study shows that the R162A mutation reduces but stabilizes NanoLuc activity, identified through molecular dynamics simulations and mutational analysis.

A Brighter picALuc Generated Through the Loss of a Salt Bridge Interaction

This paper identifies a salt bridge interaction loss in picALuc that increases its enzymatic activity through structural modeling, MD simulations, and mutational analysis.

SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to downregulate MHC-I surface expression

This paper identifies two distinct mechanisms by which SARS-CoV-2 accessory proteins ORF7a and ORF3a downregulate MHC-I surface expression to evade immune detection.

A Genetically Encoded BRET-based SARS-CoV-2 Mpro Protease Activity Sensor

This paper develops BRET-based sensors to detect SARS-CoV-2 Mpro protease activity in live cells and in vitro, showing improved sensitivity and specificity over existing methods.

Probe the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility

The paper investigates how EphA2 receptor clustering affects signaling efficiency by using substrates with controlled ligand mobility, finding that clustering increases phosphorylation and binding dwell time for signaling modules.

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex

This paper uses molecular dynamics simulations to show that the N501Y mutation in SARS-CoV-2 S1-RBD increases ACE2 binding affinity by stabilizing interfacial interactions and altering dynamics.