Author

K. H. Maclachlan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

B. T. Diamond· 3 shared F. Maura· 3 shared G. Morgan· 3 shared O. Landgren· 3 shared B. Ziccheddu· 2 shared N. Bolli· 2 shared S. Usmani· 2 shared Y. Zhang· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCancer Biology

B. T. Diamond

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4 papers

Recent·Most cited

Gene interaction network analysis in multiple myeloma detects complex immune dysregulation associated with shorter survival

A. K. Simhal, K. H. Maclachlan, R. H. Elkin, J. Zhu, L. Norton, J. O. Deasy, J. H. Oh, S. Z. Usmani, A. R. Tannenbaum

This study uses gene interaction network analysis in multiple myeloma to identify immune-related genes associated with shorter survival.

bioRxiv · Apr 5, 2023Cancer Biology

Impact of rare structural variant events in newly diagnosed multiple myeloma

M. Chojnacka, B. T. Diamond, B. Ziccheddu, E. Rustad, K. H. Maclachlan, M. Papadimitriou, E. M. Boyle, P. Blaney, S. Usmani, G. Morgan, O. Landgren, F. Maura

This study examines rare structural variants in multiple myeloma patients, showing their association with gene expression changes and potential role in disease pathogenesis.

bioRxiv · Jan 3, 2023 · PreprintCancer Biology

Chemotherapy Signatures Map Evolution of Therapy-Related Myeloid Neoplasms

B. T. Diamond, B. Ziccheddu, K. H. Maclachlan, J. Taylor, E. Boyle, J. Arrango Ossa, J. T. Jahn, M. Affer, T. M. Totiger, D. G. Coffey, J. Watts, S. X. Lu, N. Bolli, K. Bolton, J. H. Park, , F. Maura

The paper reconstructs the evolutionary history of therapy-related myeloid neoplasms using chemotherapy-associated mutational signatures and identifies distinct mutational patterns linked to different chemotherapies.

bioRxiv · Apr 26, 2022 · PreprintCancer Biology

Whole genome sequencing provides evidence of two biologically and clinically distinct entities of asymptomatic monoclonal gammopathies: progressive versus stable myeloma precursor condition

B. Oben, G. Froyen, K. H. Maclachlan, D. Leongamornlert, F. Abascal, B. Zheng-Lin, V. Yellapantula, A. Derkach, E. Geerdens, B. T. Diamond, I. Arijs, B. Maes, K. Vanhees, M. Hultcrantz, E. E. Manasanch, , F. Maura

The paper uses whole genome sequencing to identify two distinct myeloma precursor conditions, progressive and stable, based on genomic features.

bioRxiv · Nov 6, 2020 · PreprintCancer Biology