Author

L. Norton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Physiology· 3 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 6 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:metabolism & bioenergetics· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

C. E. Shannon· 4 shared A. R. Tannenbaum· 3 shared J. O. Deasy· 3 shared M. Fourcaudot· 3 shared I. Ayala· 2 shared J. H. Oh· 2 shared J. P. Palavicini· 2 shared J. Zhu· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersPhysiology

C. E. Shannon

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Author profile →

10 papers

Recent·Most cited

Sex-dependent adipose glucose partitioning by the mitochondrial pyruvate carrier

C. E. Shannon, T. Bakewell, M. J. Fourcaudot, I. Ayala, G. Romero, M. Asmis, L. C. Freitas Lima, M. Wallace, L. Norton

This study investigates the role of the mitochondrial pyruvate carrier (MPC) in adipose glucose partitioning, finding sex-dependent effects on triglyceride synthesis and metabolic adaptation in mice.

bioRxiv · May 11, 2024 · PreprintPhysiology

Functional transcriptional signatures for tumor-type-agnostic phenotype prediction

C. Weistuch, K. A. Murgas, J. Zhu, L. Norton, K. A. Dill, A. R. Tannenbaum, J. O. Deasy

The paper identifies six transcriptomic archetypes from normal tissues that correlate with cancer patient survival and drug sensitivity, suggesting cancer adopts normal tissue transcriptional features.

bioRxiv · Apr 12, 2023 · PreprintCancer Biology

Gene interaction network analysis in multiple myeloma detects complex immune dysregulation associated with shorter survival

A. K. Simhal, K. H. Maclachlan, R. H. Elkin, J. Zhu, L. Norton, J. O. Deasy, J. H. Oh, S. Z. Usmani, A. R. Tannenbaum

This study uses gene interaction network analysis in multiple myeloma to identify immune-related genes associated with shorter survival.

bioRxiv · Apr 5, 2023Cancer Biology

Redox signaling regulates breast cancer metastasis via HIF1alpha-stimulated EMT dynamics and metabolic reprogramming

Z. Ren, M. Dharmaratne, H. Liang, O. Benard, M. Morales-Gallego, K. Suyama, A. T. Fard, J. C. Mar, M. Prystowsky, L. Norton, R. B. Hazan

This study shows that GPx2 loss in mammary tumors enhances metastasis through HIF1-driven EMT and metabolic changes, identified via scRNA-seq.

bioRxiv · Aug 29, 2022 · PreprintCancer Biology

Persistent Inflammatory Lipotoxicity Impedes Pancreatic β-cell Function in Diet-Induced Obese Mice Despite Correction of Glucotoxicity

I. A. Valdez, J. P. Palavicini, T. M. Bakewell, M. Fourcaudot, I. Ayala, Z. Xu, A. Khattab, X. Han, C. E. Shannon, L. Norton

This study shows that even after correcting hyperglycemia, persistent lipotoxicity from arachidonic acid and lysophosphatidylcholine impairs β-cell function in diet-induced obese mice.

bioRxiv · May 31, 2022 · PreprintPhysiology

Geometric Network Analysis Provides Prognostic Information in Patients with High Grade Serous Carcinoma of the Ovary Treated with Immune Checkpoint Inhibitors

R. Elkin, J. H. Oh, Y. L. Liu, P. Selenica, B. Weigelt, J. S. Reis-Filho, D. Zamarin, J. O. Deasy, L. Norton, A. J. Levine, A. R. Tannenbaum

This paper introduces a network curvature-based method to predict prognosis in high-grade serous ovarian cancer patients treated with immune checkpoint inhibitors using copy number alterations.

bioRxiv · Jun 10, 2021Cancer Biology

Rapid, but limited, zooplankton adaptation to simultaneous warming and acidification

H. G. Dam, J. A. deMayo, G. Park, L. Norton, X. He, M. B. Finiguerra, H. Baumann, R. S. Brennan, M. H. Pespeni

The paper shows rapid but limited adaptation in copepod populations to combined ocean warming and acidification over 25 generations.

bioRxiv · Apr 7, 2021Evolutionary Biology

Anti-tumor effects of an Id antagonist with no acquired resistance

P. M. Wojnarowicz, M. G. Escalono, Y.-H. Huang, B. Desai, Y. Chin, R. Shah, S. Xu, O. Ouerfelli, R. K. Soni, J. Philip, D. C. Montrose, J. H. Healey, V. K. Rajasekhar, W. A. Garland, L. Norton, , R. Benezra

This study demonstrates that AGX51, an Id antagonist, effectively inhibits tumor growth in multiple cancer models without inducing acquired resistance.

bioRxiv · Jan 6, 2020 · PreprintCancer Biology

Hepatic Mitochondrial Remodeling is Mechanistically Linked to Insulin Resistance in Nonalcoholic Fatty Liver Disease

C. E. Shannon, M. Ragavan, J. P. Palavicini, M. Fourcaudot, T. Bakewell, E. S. Jin, C. R. Malloy, X. Han, M. E. Merritt, L. Norton

This study links insulin resistance and mitochondrial remodeling in NAFLD, showing that insulin sensitization improves mitochondrial function without reducing lipid content.

bioRxiv · Jan 2, 2020Biochemistry

The Metabolic Effects of Angiopoietin-like protein 8 (ANGPLT8) are Differentially Regulated by Insulin and Glucose in Adipose Tissue and Liver and are Controlled by AMPK Signaling

L. Zhang, C. E. Shannon, T. M. Bakewell, M. Abdul-Ghani, M. Fourcaudot, L. Norton

This study investigates the metabolic role of ANGPTL8 in mice, showing improved glucose tolerance and reduced triglycerides, with insulin and glucose having distinct regulatory effects in liver and adipose tissue.

bioRxiv · Aug 15, 2019Physiology