O. Landgren

The Vk*MYC Mouse Model recapitulates human multiple myeloma evolution and genomic diversity

The paper develops a Vk*MYC mouse model of multiple myeloma that mirrors human disease progression, genomic diversity, and key molecular features.

Impact of rare structural variant events in newly diagnosed multiple myeloma

This study examines rare structural variants in multiple myeloma patients, showing their association with gene expression changes and potential role in disease pathogenesis.

Chemotherapy Signatures Map Evolution of Therapy-Related Myeloid Neoplasms

The paper reconstructs the evolutionary history of therapy-related myeloid neoplasms using chemotherapy-associated mutational signatures and identifies distinct mutational patterns linked to different chemotherapies.

Molecular evolution of classic Hodgkin lymphoma revealed through whole genome sequencing of Hodgkin and Reed Sternberg cells

This study uses whole genome sequencing of Hodgkin and Reed Sternberg cells to reconstruct the temporal evolution of classic Hodgkin lymphoma, identifying key mutations and structural variants.

Genomic drivers of large B-cell lymphoma resistance to CD19 CAR-T therapy

This study identifies genomic factors associated with resistance to CD19 CAR-T therapy in large B-cell lymphoma by analyzing whole genome sequencing data from treated patients.

Whole genome sequencing provides evidence of two biologically and clinically distinct entities of asymptomatic monoclonal gammopathies: progressive versus stable myeloma precursor condition

The paper uses whole genome sequencing to identify two distinct myeloma precursor conditions, progressive and stable, based on genomic features.

Accelerated single cell seeding in relapsed multiple myeloma

This study uses whole genome sequencing to show that relapsed multiple myeloma exhibits accelerated systemic seeding driven by chemotherapy-induced mutations and clonal expansion of single myeloma cells.