Author

K. J. Dechering

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Microbiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 5 Approach:experimental assay· 3 Approach:deep learning· 2 Organism:human· 2 Organism:mouse· 2 Organism:Arabidopsis· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

R. Henderson· 3 shared B. Campo· 2 shared G. Trevitt· 2 shared J. M. Bolscher· 2 shared J. Schalkwijk· 2 shared K. M. Koolen· 2 shared L. E. de Vries· 2 shared M. Llinas· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMicrobiology

R. Henderson

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Author profile →

5 papers

Recent·Most cited

A deep learning and digital archaeology approach for mosquito repellent discovery

J. N. Wei, C. Ruiz, M. Vlot, B. Sanchez-Lengeling, B. K. Lee, L. Berning, M. W. Vos, R. W. Henderson, W. W. Qian, D. M. Ando, K. M. Groetsch, R. C. Gerkin, A. B. Wiltschko, J. A. Riffell, K. J. Dechering

The paper uses a deep learning approach to discover novel mosquito repellents by training a graph neural network on historical data and testing candidates in behavioral assays.

bioRxiv · Sep 1, 2022Bioengineering

Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-out

K. J. Dechering, M. Timmerman, K. Rensen, K. M. J. Koolen, S. Honarnejad, M. Vos, T. Huijs, R. Henderson, E. Chenu, B. Laleu, B. C. Montefiore, M. D. Segall, J. E. J. Mills, E. M. Guantai, J. Duffy, M. Duffey

The paper screens a compound library against Plasmodium falciparum using a nanoluciferase assay, identifying 33 high-quality hits for antimalarial drug development.

bioRxiv · Jun 7, 2022Microbiology

The use of barcoded Asaia bacteria in mosquito in vivo screens for identification of systemic insecticides and inhibitors of malaria transmission

S. Angelika, M. Vos, R. Henderson, M. Eldering, K. Koolen, A. Sheshachalam, G. Favia, K. Samby, E. Herreros, K. J. Dechering

This paper develops a barcoding strategy using Asaia bacteria to screen for systemic insecticides and malaria transmission inhibitors in mosquitoes.

bioRxiv · Sep 29, 2021 · PreprintBioengineering

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

L. E. de Vries, P. A. Jansen, C. Barcelo, J. Munro, J. M. Verhoef, C. F. A. Pasaje, K. Rubiano, J. Striepen, J. M. Bolscher, R. Henderson, T. Huijs, K. M. Koolen, P. K. Tumwebaze, T. Yeo, A. C. Aguiar, , K. J. Dechering

This paper characterizes MMV693183, a novel antimalarial compound targeting acetyl-CoA synthetase, showing in vitro and in vivo efficacy against Plasmodium species and transmission blocking.

bioRxiv · May 12, 2021Microbiology

Antimalarial pantothenamide metabolites target acetyl-CoA synthesis in Plasmodium falciparum

J. Schalkwijk, E. L. Allman, P. A. Jansen, L. E. de Vries, S. Jackowski, P. N. Botman, C. A. Beuckens-Schortinghuis, K. M. Koolen, J. M. Bolscher, M. W. Vos, K. Miller, S. Reeves, H. Pett, G. Trevitt, S. Wittlin, , K. J. Dechering

Pantothenamides form antimetabolites that interfere with acetyl-CoA metabolism in the human malaria parasite Plasmodium falciparum.

bioRxiv · Feb 12, 2018Pharmacology & Toxicology