Author

C. F. A. Pasaje

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:plant (other)· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. C. Niles· 4 shared A. C. Aguiar· 1 shared A. Churchyard· 1 shared A. Falla· 1 shared A. S. Nasamu· 1 shared B. A. Wall· 1 shared B. C. Fernandez· 1 shared B. Campo· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersMicrobiology

J. C. Niles

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Author profile →

5 papers

Recent·Most cited

A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma

S. Sidik, D. Valleau, Y. Acevedo-Sanchez, L. C. Godoy, C. F. A. Pasaje, M.-H. Huynh, V. B. Carruthers, J. C. Niles, S. Lourido

The paper identifies a conserved microneme protein complex, CLAMP-SPATR-CLIP, essential for rhoptry discharge in Toxoplasma gondii.

bioRxiv · Nov 28, 2022 · PreprintMicrobiology

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

L. E. de Vries, P. A. Jansen, C. Barcelo, J. Munro, J. M. Verhoef, C. F. A. Pasaje, K. Rubiano, J. Striepen, J. M. Bolscher, R. Henderson, T. Huijs, K. M. Koolen, P. K. Tumwebaze, T. Yeo, A. C. Aguiar, , K. J. Dechering

This paper characterizes MMV693183, a novel antimalarial compound targeting acetyl-CoA synthetase, showing in vitro and in vivo efficacy against Plasmodium species and transmission blocking.

bioRxiv · May 12, 2021Microbiology

Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo

M. Chew, W. Ye, R. I. Omelianczyk, C. F. A. Pasaje, R. Hoo, Q. Chen, J. C. Niles, J. Chen, P. Preiser

This study identifies parasite variant surface antigens that help Plasmodium falciparum evade immune clearance in vivo using a humanized mouse model.

bioRxiv · Jul 22, 2020Microbiology

Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death

K.-Y. Lu, C. F. A. Pasaje, T. Srivastava, D. R. Loiselle, J. Niles, E. Derbyshire

This study identifies PI(3)P and PfHsp70-1 as factors protecting Plasmodium falciparum from heat-induced cell death by stabilizing the digestive vacuole.

bioRxiv · Mar 17, 2020Microbiology

An integrated platform for genome engineering and gene expression perturbation in Plasmodium falciparum

A. S. Nasamu, A. Falla, C. F. A. Pasaje, B. A. Wall, J. C. Wagner, S. M. Ganesan, S. J. Goldfless, J. C. Niles

This paper develops a DNA assembly framework to overcome challenges in genome engineering for Plasmodium falciparum by using linear plasmids for high AT-content DNA constructs.

bioRxiv · Oct 24, 2019Microbiology