Author

L. E. de Vries

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:metabolomics· 1

Frequent Co-Authors

B. Campo· 2 shared G. Trevitt· 2 shared J. M. Bolscher· 2 shared J. Schalkwijk· 2 shared K. J. Dechering· 2 shared K. M. Koolen· 2 shared M. Llinas· 2 shared P. A. Jansen· 2 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

B. Campo

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Author profile →

4 papers

Recent·Most cited

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

L. E. de Vries, P. A. Jansen, C. Barcelo, J. Munro, J. M. Verhoef, C. F. A. Pasaje, K. Rubiano, J. Striepen, J. M. Bolscher, R. Henderson, T. Huijs, K. M. Koolen, P. K. Tumwebaze, T. Yeo, A. C. Aguiar, , K. J. Dechering

This paper characterizes MMV693183, a novel antimalarial compound targeting acetyl-CoA synthetase, showing in vitro and in vivo efficacy against Plasmodium species and transmission blocking.

bioRxiv · May 12, 2021Microbiology

Conjugative dissemination of plasmids in rapid sand filters: a trojan horse strategy to enhance pesticide degradation in groundwater treatment

R. Pinilla-Redondo, A. K. Olsen, J. Russel, L. E. de Vries, L. D. Christensen, S. Musovic, J. Nesme, S. J. Soerensen

bioRxiv · Mar 6, 2020 · PreprintMicrobiology

Antimalarial pantothenamide metabolites target acetyl-CoA synthesis in Plasmodium falciparum

J. Schalkwijk, E. L. Allman, P. A. Jansen, L. E. de Vries, S. Jackowski, P. N. Botman, C. A. Beuckens-Schortinghuis, K. M. Koolen, J. M. Bolscher, M. W. Vos, K. Miller, S. Reeves, H. Pett, G. Trevitt, S. Wittlin, , K. J. Dechering

Pantothenamides form antimetabolites that interfere with acetyl-CoA metabolism in the human malaria parasite Plasmodium falciparum.

bioRxiv · Feb 12, 2018Pharmacology & Toxicology

Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite

C. Lehmann, M. S. Y. Tan, L. E. de Vries, I. Russo, M. I. Sanchez, D. E. Goldberg, E. Deu

This study shows that DPAP3 protease activity is crucial for Plasmodium falciparum erythrocyte invasion but not egress.

bioRxiv · Nov 8, 2017Microbiology