Author

K. J. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Physiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Organism:Arabidopsis· 1

Frequent Co-Authors

E. G. Canty-Laird· 2 shared P. D. Clegg· 2 shared A. Carter· 1 shared A. D. Abell· 1 shared A. P. Thompson· 1 shared A. Voxeur· 1 shared B. I. Gaiser· 1 shared C. G. Piett· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersPhysiology

E. G. Canty-Laird

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Author profile →

5 papers

Recent·Most cited

Fortuitous in vitro compound degradation produces a tractable hit against Mycobacterium tuberculosis dethiobiotin synthetase: a cautionary tale of what goes in, does not always come out

W. Salaemae, A. P. Thompson, B. I. Gaiser, K. J. Lee, M. T. Huxley, C. J. Sumby, S. W. Polyak, A. D. Abell, J. B. Bruning, K. L. Wegener

The paper describes how a fragment compound was inadvertently modified in crystal conditions, leading to a potent inhibitor of Mycobacterium tuberculosis dethiobiotin synthetase.

bioRxiv · Mar 26, 2023 · PreprintBiochemistry

Pectin remodeling belongs to a homeostatic system and triggers transcriptomic and hormonal modulations

F. Jobert, S. Guenin, A. Voxeur, K. J. Lee, S. Bouton, F. Senechal, L. Hocq, G. Mongelard, H. Demailly, P. Amakorova, M. Strnad, S. Vernhettes, G. Mouille, S. Pilard, P. Knox, , L. Gutierrez

The paper investigates how pectin methylesterification status affects seed-to-seedling transition by altering transcriptomic and hormonal profiles in Arabidopsis.

bioRxiv · Jul 22, 2021 · PreprintPlant Biology

Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice

K. J. Lee, L. Rambault, G. Bou-Gharios, P. D. Clegg, R. Akhtar, G. Czanner, R. J. van 't Hof, E. G. Canty-Laird

This study shows that homotrimeric collagen-1 in oim heterozygotes alleviates the mutant allele's effect, but genetic interaction causes bone fragility in oim homozygotes.

bioRxiv · Jul 13, 2020Physiology

Active synthesis of type I collagen homotrimer in Dupuytren's fibrosis is unaffected by anti-TNF-α treatment

K. Williamson, K. J. Lee, E. L. Beamish, A. Carter, J. A. Gumbs, G. Cooper, G. Cheung, D. Brown, R. Pettitt, E. J. Comerford, P. D. Clegg, E. G. Canty-Laird

This study investigates type I collagen synthesis in Dupuytrens disease and finds anti-TNF-α treatment does not reduce collagen production or prevent homotrimer formation.

bioRxiv · Jul 13, 2020Cell Biology

Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer

K. J. Lee, C. G. Piett, J. F. Andrews, E. Mann, Z. D. Nagel, N. R. Gassman

The paper evaluates XRCC1 expression and localization in triple negative breast cancer to assess BER defects and their correlation with DNA damage and repair capacity.

bioRxiv · Jun 27, 2019Cancer Biology