Author

K. Keeshan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

K. Blyth· 2 shared A. E. Davis· 1 shared A. Newcombe· 1 shared A.-L. Latif· 1 shared B. Higgens· 1 shared C. McKeeve· 1 shared C. Reid· 1 shared G. Naylor· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

K. Blyth

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2 papers

Recent·Most cited

Caspase-resistant ROCK1 expression prolongs survival of E-mu-Myc B cell lymphoma mice.

K. Mardilovich, G. Naylor, L. Julian, N. Phinichkusolchit, K. Keeshan, K. Blyth, M. F. Olson

This study shows that expressing caspase-resistant ROCK1 in B cell lymphoma mice prolongs survival by reducing cell numbers and creating a proliferation-suppressive bone marrow microenvironment.

bioRxiv · Feb 26, 2024 · PreprintCancer Biology

BRD4-mediated repression of p53 is a target for combination therapy in AML

A.-L. Latif, A. Newcombe, S. Li, K. Gilroy, N. Robertson, X. Lei, H. Stewart, J. Cole, M. T. Terradas, L. Rishi, L. McGarry, C. McKeeve, C. Reid, W. Clark, J. Campos, , P. D. Adams

This study shows that combining MDM2 inhibitors and BET inhibitors synergistically kills AML cells by enhancing p53 activation through BRD4's repressive function.

bioRxiv · Sep 16, 2020Cell Biology