J. Campos

Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing

This study uses retrograde tracing to characterize neuron-tumor networks in glioblastoma and shows that targeting these networks can enhance therapeutic outcomes.

SCD inhibition eradicates AML displaying high de novo fatty acid desaturation and synergizes with chemotherapy

SCD inhibition induces AML cell death and synergizes with chemotherapy to prolong survival in murine AML models.

ACE2 mimetic antibody potently neutralizes all SARS-CoV-2 variants and fully protects in XBB.1.5 challenged monkeys

The phenuivirus Toscana virus makes an atypical use of vacuolar acidity to enter host cells

This study identifies Toscana virus as a late-penetrating virus that uses vacuolar acidity for entry, with an optimal fusion pH of 5.5 and infectious particles remaining viable below this threshold.

A time and single-cell resolved model of hematopoiesis

The paper builds a real-time, quantitative model of hematopoiesis using time-series single-cell RNA-Seq and persistent labeling, revealing lineage-specific self-renewal and differentiation properties.

SARS-CoV-2 Omicron potently neutralized by a novel antibody with unique Spike binding properties

This paper identifies a potent human monoclonal antibody, P2G3, that neutralizes multiple SARS-CoV-2 variants including Omicron, and demonstrates its protective efficacy in a monkey model.

Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages

This study identifies fibroblastic reticular cells (FRCs) as essential for supporting lymph node-resident macrophages through CSF1 and CSF1R signaling.

Mild impairment of mitochondrial function increases longevity and pathogen resistance through ATFS-1-driven activation of p38-regulated innate immunity

This paper shows that mild mitochondrial dysfunction in C. elegans extends lifespan and enhances pathogen resistance via ATFS-1-driven activation of p38-regulated innate immunity.

CLEC-2 promotes inflammatory peritoneal macrophage emigration to draining lymph nodes during endotoxemia

This study identifies that recombinant CLEC-2-Fc promotes the emigration of inflammatory peritoneal macrophages to draining lymph nodes, reducing local inflammation during endotoxemia.

BRD4-mediated repression of p53 is a target for combination therapy in AML

This study shows that combining MDM2 inhibitors and BET inhibitors synergistically kills AML cells by enhancing p53 activation through BRD4's repressive function.

VE-cadherin endocytosis controls vascular integrity and patterning during development

This study shows that VE-cadherin endocytosis is essential for vascular development by promoting actin-dependent cell migration and vessel stabilization through p120 binding.

Pathologically distinct fibroblast subsets drive inflammation and tissue damage in arthritis

The paper identifies two distinct fibroblast subsets in arthritis that drive inflammation or tissue damage, showing their unique roles in disease progression.