Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics
A. Koessinger, D. Koessinger, K. Kinch, L. Martinez-Escardo, N. Paul, Y. Elmasry, G. Malviya, C. Cloix, K. Campbell, F. Bock, J. O'Prey, K. Stevenson, C. Nixon, M. Jackson, G. Ichim, , S. Tait
This study shows that glioblastoma (GBM) is highly sensitive to BH3-mimetics due to elevated anti-apoptotic BCL-xL and MCL-1 expression, which can be therapeutically targeted.
bioRxiv · Jun 13, 2021 · PreprintCancer Biology